BACKGROUND Cardiac adipose tissue may have local paracrine effects on epicardial arteries and the underlying myocardium, promoting calcification and affecting myocardial microcirculation. We explored whether the total amount of cardiac adipose tissue was associated with coronary artery calcium score (CAC) and myocardial flow reserve in persons with type 1 or type 2 diabetes and healthy controls. METHODS We studied three groups: (1) 30 controls, (2) 60 persons with type 1 diabetes and (3) 60 persons with type 2 diabetes. The three groups were matched for sex and age. The three groups derived from retrospective analysis of two clinical studies. All underwent cardiac 82Rb positron emission tomography/computed tomography (PET/CT) scanning. Cardiac adipose tissue volume (the sum of epicardial and pericardial fat), CAC, and myocardial flow reserve (ratio of pharmacological stress flow and rest flow) were evaluated using semiautomatic software. We applied linear regression to assess the association between cardiac adipose tissue, CAC and myocardial flow reserve. RESULTS Mean (SD) cardiac adipose tissue volume was 99 (61) mL in the control group, 106 (78) mL in the type 1 diabetes group and 228 (97) mL in the type 2 diabetes group. Cardiac adipose tissue was positively associated with body mass index in all three groups (p ≤ 0.02). In the controls, cardiac adipose tissue was positively associated with CAC score (p = 0.008) and negatively associated with myocardial flow reserve (p = 0.005). However, cardiac adipose tissue was not associated with CAC or myocardial flow reserve in the groups including persons with type 1 or type 2 diabetes (p ≥ 0.50). CONCLUSIONS In contrast to what was found in healthy controls, we could not establish a relation between cardiac adipose tissue and coronary calcification or myocardial microvascular function in person with type 1 or type 2 diabetes. The role of cardiac adipose tissue in cardiovascular disease in diabetes remains unclear.

中文翻译：

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1型和2型糖尿病患者心脏脂肪组织与冠状动脉钙化和心肌微血管功能的关系。

背景技术心脏脂肪组织可能对心外膜动脉和基础心肌具有局部旁分泌作用，从而促进钙化并影响心肌微循环。我们探讨了1型或2型糖尿病患者和健康对照者的心脏脂肪组织总量是否与冠状动脉钙分数（CAC）和心肌血流储备相关。方法我们研究了三组患者：（1）30名对照组，（2）60例1型糖尿病患者和（3）60例2型糖尿病患者。这三组人的性别和年龄相匹配。这三组源自对两项临床研究的回顾性分析。所有患者均接受了心脏82Rb正电子发射断层扫描/计算机断层扫描（PET / CT）扫描。心脏脂肪组织体积（心外膜和心包脂肪的总和），CAC，使用半自动软件评估心肌血流储备（药理学压力血流与静息血流之比）。我们应用线性回归来评估心脏脂肪组织，CAC和心肌血流储备之间的关联。结果对照组的平均心脏脂肪组织体积为99（61）mL，1型糖尿病组为106（78）mL，2型糖尿病组为228（97）mL。在所有三组中，心脏脂肪组织与体重指数均呈正相关（p≤0.02）。在对照组中，心脏脂肪组织与CAC评分呈正相关（p = 0.008），与心肌血流储备呈负相关（p = 0.005）。但是，在包括1型或2型糖尿病患者中，心脏脂肪组织与CAC或心肌血流储备无关（p≥0.50）。结论与健康对照相比，我们无法在1型或2型糖尿病患者中建立心脏脂肪组织与冠状动脉钙化或心肌微血管功能之间的关系。心脏脂肪组织在糖尿病心血管疾病中的作用尚不清楚。