BACKGROUND The aim of our study was to perform a systematic review of the literature and meta-analysis in order to investigate relationship between drug use and oral health. METHODS We searched for studies in English published before July 1, 2019 on PsycINFO, PubMed, SciELO, Scopus, and Web of Science. We assessed the relationship between drug use (methamphetamines, heroin; opiates; crack, cocaine and cannabis as dependent variables) and reported tooth loss, periodontal disease, or decayed, missing, and filled teeth index as an independent variable. The data were analyzed using Stata 12.0 software. RESULTS We initially identified 1836 potential articles (with 1100 duplicates) and screened the remaining 736 titles and abstracts, comprising 54 studies. In the next step, we evaluated the full-texts; 44 studies were excluded, accordingly. In total, we included 10 publications in the meta-analysis. Drug type was associated with periodontal disease (OR 1.44; 95% CI 0.8-2.6) and pooled estimates showed that type of drug used increased the odds of the number of decayed, missed and filled teeth (DMFT) (OR 4.11; 95% CI 2.07-8.15) respectively. CONCLUSIONS The analytical challenges of segregating the impact of individual drug types on oral health diseases mean that investigations on the direct relationship between oral health status and drug use are limited. Developing programs to improve potential confounding with various substances and addressing the dental health needs of people who use drugs is vital if we are to improve their overall quality of life.

中文翻译：

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吸毒者的龋齿和牙周病：系统评价和荟萃分析。


背景我们研究的目的是对文献进行系统回顾和荟萃分析，以调查药物使用与口腔健康之间的关系。方法 我们检索了 2019 年 7 月 1 日之前在 PsycINFO、PubMed、SciELO、Scopus 和 Web of Science 上发表的英文研究。我们评估了药物使用（甲基苯丙胺、海洛因、阿片类药物、强效快克、可卡因和大麻作为因变量）之间的关系，并报告牙齿脱落、牙周病或腐烂、缺失和补牙指数作为自变量。使用Stata 12.0软件对数据进行分析。结果 我们最初确定了 1836 篇潜在文章（其中 1100 篇重复），并筛选了其余 736 篇标题和摘要，其中包括 54 项研究。下一步，我们评估全文；因此，44 项研究被排除在外。我们总共在荟萃分析中纳入了 10 篇出版物。药物类型与牙周病相关（OR 1.44；95% CI 0.8-2.6），汇总估计显示，使用的药物类型会增加蛀牙、缺失和补牙 (DMFT) 数量的几率（OR 4.11；95% CI 2.07-8.15）分别。结论 区分各种药物类型对口腔健康疾病影响的分析挑战意味着对口腔健康状况与药物使用之间直接关系的研究是有限的。如果我们要提高吸毒者的整体生活质量，制定计划来改善与各种物质的潜在混淆并解决吸毒者的牙齿健康需求至关重要。