BACKGROUND Screening for osteoporosis with dual-energy X-ray absorptiometry (DXA) is recommended for male HIV-infected patients only above the age of 50. Recently, trabecular bone score (TBS) has been introduced as a novel tool to assess bone microarchitecture using DXA of the lumbar spine. Few studies have reported TBS values in HIV-infected individuals younger than 50 years of age. This study compared TBS values in young males infected with HIV and matched controls, and investigated the associations between TBS and demographic parameters, clinical parameters, and bone mineral density (BMD) scores. METHODS A cross-sectional study of BMD and TBS in HIV-infected men (n = 80) aged between 18 and 50 years and age- and sex-matched controls (n = 80) was conducted. RESULTS The proportion of patients with low BMD (Z-score ≤ - 2) was significantly greater among HIV-infected patients than among matched controls (21.3% [17/80] vs. 8.8% [7/80], p = 0.027). Mean TBS values were significantly lower in HIV-infected patients than in controls (1.41 ± 0.07 vs. 1.45 ± 0.07, p = 0.008). In both groups, TBS values were positively correlated with BMD at the lumbar spine, femoral neck, and total hip (p < 0.001); however, TBS was not correlated with body mass index. In the HIV group, TBS was negatively correlated with the duration of tenofovir disoproxil fumarate(TDF) exposure (p = 0.04). CONCLUSION Young men infected with HIV had abnormal bone trabecular microarchitecture, as assessed by both TBS and BMD. TBS values were correlated with both BMD and the duration of TDF exposure.

中文翻译：

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艾滋病毒感染青年男性的骨小梁评分：一项匹配的病例对照研究。

背景技术建议仅在50岁以上的男性HIV感染患者中使用双能X射线吸收法（DXA）筛查骨质疏松症。最近，小梁骨评分（TBS）已被引入作为评估骨微结构的新工具腰椎的DXA。很少有研究报道50岁以下的HIV感染者的TBS值。这项研究比较了感染艾滋病毒的年轻男性和配对对照中的TBS值，并研究了TBS与人口统计学参数，临床参数和骨矿物质密度（BMD）得分之间的关​​联。方法对18至50岁的HIV感染男性（n = 80）以及年龄和性别相匹配的对照组（n = 80）进行了BMD和TBS横断面研究。结果HIV感染患者中BMD低（Z分数≤-2）的患者比例显着高于配对对照组（21.3％[17/80]对8.8％[7/80]，p = 0.027） 。HIV感染患者的平均TBS值显着低于对照组（1.41±0.07对1.45±0.07，p = 0.008）。两组中，腰椎，股骨颈和全髋部的TBS值均与BMD呈正相关（p <0.001）。然而，TBS与体重指数无关。在HIV组中，TBS与替诺福韦富马酸替诺福韦酯（TDF）的暴露时间呈负相关（p = 0.04）。结论根据TBS和BMD评估，感染HIV的年轻男性的骨小梁微结构异常。TBS值与BMD和TDF暴露持续时间相关。