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The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
Antiviral Research ( IF 4.5 ) Pub Date : 2020-02-10 , DOI: 10.1016/j.antiviral.2020.104742 B Coutard 1 , C Valle 2 , X de Lamballerie 1 , B Canard 2 , N G Seidah 3 , E Decroly 2
Antiviral Research ( IF 4.5 ) Pub Date : 2020-02-10 , DOI: 10.1016/j.antiviral.2020.104742 B Coutard 1 , C Valle 2 , X de Lamballerie 1 , B Canard 2 , N G Seidah 3 , E Decroly 2
Affiliation
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
更新日期：2020-02-10
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