The mammalian meat allergy known as the "α-Gal syndrome" relates to IgE specific for galactose-α-1,3-galactose (α-Gal), an oligosaccharide that is present in cells and tissues of nonprimate mammals. The recognition of delayed reactions to food derived from mammals in patients with IgE to α-Gal and also the association with tick bites have been increasing worldwide. In 2018, the National Institute of Allergy and Infectious Diseases, Division of Allergy, Immunology and Transplantation, sponsored a workshop on this emerging tick-related disease. International experts from the fields of tick biology, allergy, immunology, infectious disease, and dermatology discussed the current state of our understanding of this emerging medical condition. The participants provided suggestions for specific research priorities and for the development of resources to advance our knowledge of the mechanisms, diagnosis, management, and prevention of this allergic disease. This publication is a summary of the workshop and the panel's recommendations are presented herein.

中文翻译：

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关于 IgE 对半乳糖-α-1,3-半乳糖的原因和后果：国家过敏和传染病研究所关于了解 IgE 介导的哺乳动物肉过敏研讨会的报告。

被称为“α-Gal 综合征”的哺乳动物肉类过敏症与半乳糖-α-1,3-半乳糖 (α-Gal) 特异性 IgE 相关，半乳糖-α-1,3-半乳糖 (α-Gal) 是一种存在于非灵长类哺乳动物细胞和组织中的低聚糖。IgE 患者对来自哺乳动物的食物的延迟反应对 α-Gal 的认识以及与蜱叮咬的关联在世界范围内不断增加。2018 年，美国国家过敏和传染病研究所过敏、免疫学和移植部主办了一个关于这种新兴蜱相关疾病的研讨会。来自蜱生物学、过敏症、免疫学、传染病和皮肤病学领域的国际专家讨论了我们对这种新兴疾病的理解现状。参与者就具体的研究重点和资源开发提出了建议，以提高我们对这种过敏性疾病的机制、诊断、管理和预防的认识。本出版物是研讨会的摘要，此处介绍了专家组的建议。