Aggregation-Induced Emission Photosensitizers: From Molecular Design to Photodynamic Therapy.,Journal of Medicinal Chemistry

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Aggregation-Induced Emission Photosensitizers: From Molecular Design to Photodynamic Therapy.
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2020-02-17 , DOI: 10.1021/acs.jmedchem.9b02014
Jun Dai ₁ , Xia Wu ₂ , Siyang Ding ₃ , Xiaoding Lou ₂ , Fan Xia ₂ , Shixuan Wang ₁ , Yuning Hong ₃

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Photodynamic therapy (PDT) has emerged as a promising noninvasive treatment option for cancers and other diseases. The key factor that determines the effectiveness of PDT is the photosensitizers (PSs). Upon light irradiation, the PSs would be activated, produce reactive oxygen species (ROS), and induce cell death. One of the challenges is that traditional PSs adopt a large flat disc-like structure, which tend to interact with the adjacent molecules through strong π-π stacking that reduces their ROS generation ability. Aggregation-induced emission (AIE) molecules with a twisted configuration to suppress strong intermolecular interactions represent a new class of PSs for image-guided PDT. In this Miniperspective, we summarize the recent progress on the design rationale of AIE-PSs and the strategies to achieve desirable theranostic applications in cancers. Subsequently, approaches of combining AIE-PS with other imaging and treatment modalities, challenges, and future directions are addressed.

中文翻译：

聚集诱导的光敏剂：从分子设计到光动力疗法。

光动力疗法（PDT）已经成为一种有希望的针对癌症和其他疾病的非侵入性治疗选择。决定PDT有效性的关键因素是光敏剂（PSs）。在光照射下，PS将被激活，产生活性氧（ROS），并诱导细胞死亡。挑战之一是传统PS采用大的扁平圆盘状结构，这种结构倾向于通过强大的π-π堆叠与相邻分子相互作用，从而降低其ROS生成能力。具有扭曲构型以抑制强烈的分子间相互作用的聚集诱导发射（AIE）分子代表了图像引导PDT的一类新型PS。在这个迷你视野中我们总结了AIE-PS设计原理的最新进展以及在癌症中实现理想的治疗学应用的策略。随后，提出了将AIE-PS与其他成像和治疗方式，挑战和未来方向相结合的方法。

更新日期：2020-02-17

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