Research efforts in the past decades have provided insight into the adverse health effects of air pollution exposure. Exposure to airborne particulate matter is known to impair the respiratory and cardiovascular systems, and more recent investigations have provided evidence demonstrating harmful effects on the central nervous system. Investigations have primarily focused on the interconnected cellular pathways of inflammation and oxidative stress, which are induced by pollutant particle exposure both in peripheral tissues, and in the brain. Alterations to mitochondria, organelles important for cellular respiration and signaling, are often associated with increased cellular oxidative stress. This review focuses on the role of mitochondria in particulate matter-induced adverse effects on cellular health. More investigation to link air pollution and human health on the cellular and molecular level could in the future aid the development of more effective preventive and therapeutic options to combat pollutant particle-induced alterations.

中文翻译：

---

颗粒物对线粒体功能的损害：对大脑的影响。

在过去的几十年中，研究工作已经使人们了解了空气污染暴露对健康的不利影响。暴露于空气中的颗粒物已知会损害呼吸系统和心血管系统，最近的研究提供了证明对中枢神经系统有害的证据。研究主要集中在炎症和氧化应激的相互联系的细胞途径上，炎症和氧化应激是由周围组织和大脑中的污染物颗粒暴露引起的。线粒体是细胞呼吸和信号传导重要的细胞器，线粒体的改变通常与细胞氧化应激增加有关。这篇综述集中于线粒体在颗粒物诱导的对细胞健康的不利影响中的作用。