Until recently, autoimmune disease research has primarily been focused on elucidating the role of the adaptive immune system. In the past decade or so, the role of the innate immune system in the pathogenesis of autoimmunity has increasingly been realized. Recent findings have elucidated paradigm-shifting concepts, for example, the implications of "trained immunity" and a dysbiotic microbiome in the susceptibility of predisposed individuals to clinical autoimmunity. In addition, the application of modern technologies such as the quantum dot (Qdot) system and 'Omics' (e.g., genomics, proteomics, and metabolomics) data-processing tools has proven fruitful in revisiting mechanisms underlying autoimmune pathogenesis and in identifying novel therapeutic targets. This review highlights recent findings discussed at the American Autoimmune Related Disease Association (AARDA) 2019 colloquium. The findings covering autoimmune diseases and autoinflammatory diseases illustrate how new developments in common innate immune pathways can contribute to the better understanding and management of these immune-mediated disorders.

中文翻译：

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自身免疫性疾病的常见先天途径。

直到最近，自身免疫疾病的研究主要集中在阐明适应性免疫系统的作用上。在过去十年左右的时间里，先天免疫系统在自身免疫病发病机制中的作用越来越被认识到。最近的研究结果阐明了范式转换概念，例如，“受过训练的免疫”和失调的微生物组对易感个体对临床自身免疫的易感性的影响。此外，现代技术的应用，如量子点 (Qdot) 系统和“组学”（例如，基因组学、蛋白质组学和代谢组学）数据处理工具在重新审视自身免疫发病机制和确定新的治疗靶点方面卓有成效。 . 本综述重点介绍了美国自身免疫相关疾病协会 (AARDA) 2019 年座谈会中讨论的最新发现。涵盖自身免疫性疾病和自身炎症性疾病的发现说明了常见先天免疫途径的新发展如何有助于更好地理解和管理这些免疫介导的疾病。