We studied 156 individuals with acute, right hemisphere ischemic stroke on a battery of hemispatial neglect tests to distinguish between viewer-centered and stimulus-centered neglect and MRI diffusion weighted imaging. We identified the relative contributions of age, total lesion volume, and damage to subcortical and cortical grey matter regions as well as white matter tracts to both the severity and presence of significant viewer-centered and stimulus-centered neglect, using multivariable regression tests. We found that age, volume of lesion, and percent damage to the regions of interest were each independently associated with the severity of viewer-centered neglect (r2 = .31; p < .0001). However, only age (t = 3.20; p = .002) and percent damage to the angular gyrus (t = 2.63, p = .010), a dorsal stream area, predicted severity of viewer-centered neglect independently of the other variables. The same variables predicted the presence of significant viewer-centered neglect. In contrast, these variables did not significantly predict the severity of stimulus-centered neglect. However, we found that percent damage to ventral stream regions of interest (middle temporal gyrus, inferior temporal gyrus, fusiform gyrus, inferior frontal occipital gyrus, sagittal stratum, along with total infarct volume were associated with the presence of significant stimulus-centered neglect (pseudo r2 = .70, p < .0004). Only percent damage to right inferior temporal gyrus predicted stimulus-centered neglect independently of the other variables (p = .018).

中文翻译：

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在急性右半球卒中中，年龄，病变量以及对背侧和腹侧流的损害对以观察者和刺激为中心的半pat漏的影响。

我们通过一系列半pat觉忽视测试研究了156名急性，右半球缺血性卒中患者，以区分以观察者为中心和以刺激为中心的忽视以及MRI扩散加权成像。我们使用多变量回归检验，确定了年龄，总病变体积，皮层下和皮质灰质区域以及白质束的损害对严重程度以及是否存在以观看者为中心和以刺激为中心的重大忽视的相对贡献。我们发现年龄，病变部位和对目标区域的损害百分比均与以观看者为中心的忽视的严重程度独立相关（r2 = .31； p <.0001）。但是，只有年龄（t = 3.20； p = .002）和对角回的百分比损伤（t = 2.63，p = .010），即背河区域，独立于其他变量，以观看者为中心的预测严重性忽略不计。相同的变量预示着以观看者为中心的重大忽视。相反，这些变量并不能明显预测以刺激为中心的忽视的严重性。但是，我们发现感兴趣的腹侧气流区域（中颞回，颞下回，梭状回，额枕下回，矢状位）以及总梗死体积的受损百分比与以刺激为中心的明显忽视有关（假r2 = .70，p <.0004）。只有右下颞回损伤的百分比预测与其他变量无关的以刺激为中心的疏忽（p = .018）。相同的变量预示着以观看者为中心的重大忽视。相反，这些变量并不能明显预测以刺激为中心的忽视的严重性。但是，我们发现感兴趣的腹侧气流区域（中颞回，颞下回，梭状回，额枕下回，矢状位）以及总梗死体积的受损百分比与以刺激为中心的明显忽视有关（假r2 = .70，p <.0004）。只有右下颞回损伤的百分比预测与其他变量无关的以刺激为中心的疏忽（p = .018）。相同的变量预示着以观看者为中心的重大忽视。相反，这些变量并不能明显预测以刺激为中心的忽视的严重性。但是，我们发现感兴趣的腹侧气流区域（中颞回，颞下回，梭状回，额枕下回，矢状位）以及总梗死体积的受损百分比与以刺激为中心的明显忽视有关（假r2 = .70，p <.0004）。只有右下颞回损伤的百分比预测与其他变量无关的以刺激为中心的疏忽（p = .018）。