The concept of chronic obstructive pulmonary disease (COPD) control has been proposed to guide treatment decisions in COPD. In this study, we aimed to validate the prospective value of this concept in the SPARK study population. Control was assessed based on COPD stability and impact. Patients with low impact and stability during weeks 1–12 were classified as controlled, and exacerbations were measured during a 52-week follow-up. Of the 2044 patients included a majority were non-controlled (80%), frequently due to high impact. During the follow-up, the rate of moderate/severe exacerbations was significantly lower in controlled patients (rate ratio, 0.56, 95% CI 0.48 to 0.65 p<0.0001) and time-to-first moderate/severe exacerbation was significantly delayed. This study demonstrated an association between control status and risk of exacerbations.

中文翻译：

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COPD 临床控制作为未来恶化的预测指标：SPARK 研究人群中的概念验证

已提出慢性阻塞性肺疾病 (COPD) 控制的概念来指导 COPD 的治疗决策。在本研究中，我们旨在验证这一概念在 SPARK 研究人群中的前瞻性价值。基于COPD稳定性和影响评估控制。在第 1-12 周内影响力和稳定性较低的患者被归类为受控，并在 52 周的随访期间测量恶化。在包括的 2044 名患者中，大多数是未控制的 (80%)，通常是由于高影响。在随访期间，对照患者的中度/重度恶化率显着降低（比率比，0.56，95% CI 0.48 至 0.65 p<0.0001），并且至第一次中度/重度恶化的时间显着延迟。该研究证明了控制状态与恶化风险之间的关联。