Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory.,Nature Neuroscience

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Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2020-02-10 , DOI: 10.1038/s41593-020-0588-8
Fei Wang ₁ , Shu-Yu Ren ₁ , Jing-Fei Chen ₁ , Kun Liu ₁ , Rui-Xue Li ₁ , Zhi-Fang Li _{1,

2} , Bo Hu ₃ , Jian-Qin Niu ₁ , Lan Xiao ₁ , Jonah R Chan ₄ , Feng Mei ₁

Affiliation

Cognitive decline remains an unaddressed problem for the elderly. We show that myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte precursor cells impairs spatial memory in young mice, while enhancing myelination by deleting the muscarinic acetylcholine receptor 1 in oligodendrocyte precursor cells, or promoting oligodendroglial differentiation and myelination via clemastine treatment, rescues spatial memory decline during aging.

中文翻译：

髓磷脂变性和髓鞘更新减少导致与年龄有关的记忆缺陷。

认知能力下降仍然是老年人尚未解决的问题。我们表明，髓鞘形成在年轻小鼠中高度活跃，并在老年小鼠中受到极大抑制，与空间记忆缺陷相吻合。通过缺失少突胶质细胞前体细胞中的Olig2抑制髓鞘形成损害了幼鼠的空间记忆，同时通过缺失少突胶质细胞前体细胞中的毒蕈碱型乙酰胆碱受体1来增强髓鞘形成，或通过clemastine治疗促进少突胶质细胞分化和髓鞘形成，从而挽救了衰老过程中空间记忆的下降。

更新日期：2020-02-10

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