A Rh(III)-catalyzed regioselective intermolecular oxa-Pauson–Khand reaction of alkynes, arylboronic acids and CO to form butenolides,Organic Chemistry Frontiers

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A Rh(III)-catalyzed regioselective intermolecular oxa-Pauson–Khand reaction of alkynes, arylboronic acids and CO to form butenolides
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020/02/05 , DOI: 10.1039/c9qo01486a
Mi-Na Zhao _{1,

2,

3,

4,

5} , Ying Zhang _{1,

2,

3,

4,

5} , Ning Ge _{1,

2,

3,

4,

5} , Le Yu _{1,

2,

3,

4,

5} , Shun Wang _{1,

2,

3,

4,

5} , Zhi-Hui Ren _{1,

2,

3,

4,

5} , Zheng-Hui Guan _{1,

2,

3,

4,

5}

Affiliation

A Rh(III)-catalyzed regioselective intermolecular oxa-Pauson–Khand reaction of arylboronic acids, alkynes and CO for the synthesis of butenolides has been developed. The multi-step reaction proceeded smoothly in the presence of [RhCp*Cl₂]₂ catalyst, NaOAc base and CH₃OH additive. The reaction used readily available starting materials, tolerated various functional groups, and afforded valuable butenolides in good yields with high regioselectivity.

中文翻译：

Rh（III）催化的炔烃，芳基硼酸和CO的区域选择性分子间oxa-Pauson-Khand反应形成丁烯化物

已开发了Rh（III）催化的芳基硼酸，炔烃和CO的区域选择性分子间oxa-Pauson-Khand反应，用于合成丁烯内酯。在[RhCp * Cl ₂ ] ₂催化剂，NaOAc碱和CH ₃ OH添加剂的存在下，多步反应顺利进行。该反应使用容易获得的起始原料，耐受各种官能团，并以高收率和高区域选择性提供有价值的丁烯内酯。

更新日期：2020-03-03

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