Synthesis of aromatic terminal allenes and aliphatic terminal alkynes from hydrazones using calcium carbide as an acetylene source,Organic Chemistry Frontiers

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Synthesis of aromatic terminal allenes and aliphatic terminal alkynes from hydrazones using calcium carbide as an acetylene source
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020/01/23 , DOI: 10.1039/c9qo01400d
Lei Gao _{1,

2,

3,

4} , Zheng Li _{1,

2,

3,

4}

Affiliation

A simple method for the selective synthesis of aromatic terminal allenes and aliphatic terminal alkynes from the reactions of calcium carbide with aromatic ketone and aldehyde p-tosylhydrazones or aliphatic ketone and aldehyde p-tosylhydrazones using copper as a mediator is described. The salient features of this protocol are the use of a readily available and easy-to-handle acetylene source, operational simplicity, high yield, and broad substrate scope.

中文翻译：

以碳化钙为乙炔源，由合成芳族末端烯和脂肪族末端炔

描述了一种简单的方法，用于以铜为介体，由碳化钙与芳族酮和醛对甲苯磺酰or或脂族酮和醛对甲苯磺酰selective的反应，选择性地合成芳族末端烯和脂族末端炔。该协议的显着特征是使用易于获得且易于处理的乙炔源，操作简便，高收率和广泛的底物范围。

更新日期：2020-02-18

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