Synthesis of 4-ethenyl quinazolines via rhodium(III)-catalyzed [5 + 1] annulation reaction of N-arylamidines with cyclopropenones,Organic Chemistry Frontiers

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Synthesis of 4-ethenyl quinazolines via rhodium(III)-catalyzed [5 + 1] annulation reaction of N-arylamidines with cyclopropenones
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020/01/20 , DOI: 10.1039/c9qo01372e
Huimin Xing _{1,

2,

3,

4,

5} , Jian Chen _{1,

2,

3,

4,

5} , Yuesen Shi _{1,

2,

3,

4,

5} , Tianle Huang _{1,

2,

3,

4,

5} , Li Hai _{1,

2,

3,

4,

5} , Yong Wu _{1,

2,

3,

4,

5}

Affiliation

An unprecedented synthesis of 4-ethenyl quinazolines via a Rh(III)-catalyzed C–H activation and annulation reaction was described. In particular, when C-alkyl imidamides are benzyl groups, 2-benzoyl quinazolines can be obtained. This protocol enables the effective application of cyclopropenones, featuring high atom efficiency, broad substrate scope and mild reaction conditions.

中文翻译：

通过铑（III）催化的N-芳基idine与环丙烯酮的[5 +1]环合反应合成4-乙烯基喹唑啉

通过Rh（III）催化的C–H活化和环化反应，空前地合成了4-乙烯基喹唑啉。特别地，当C-烷基亚酰胺为苄基时，可获得2-苯甲酰基喹唑啉。该方案能够有效地应用环丙烯酮，具有高原子效率，广泛的底物范围和温和的反应条件。

更新日期：2020-02-18

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