Synthesis of indoline-piperidinones via a novel Ugi, ring expansion, pseudo-Dieckmann condensation and rearrangement cascade reaction,Organic Chemistry Frontiers

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Synthesis of indoline-piperidinones via a novel Ugi, ring expansion, pseudo-Dieckmann condensation and rearrangement cascade reaction
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020/01/22 , DOI: 10.1039/d0qo00028k
Jie Lei _{1,

2,

3,

4,

5} , Gui-Ting Song _{1,

2,

3,

4,

5} , Ya-Fei Luo _{1,

2,

3,

4,

5} , Dian-Yong Tang _{1,

2,

3,

4,

5} , Wei Yan _{1,

6,

7,

8,

9} , Hong-yu Li _{1,

6,

7,

8,

9} , Zhong-Zhu Chen _{1,

2,

3,

4,

5} , Zhi-Gang Xu _{1,

2,

3,

4,

5}

Affiliation

An Ugi, ring expansion, pseudo-Dieckmann condensation and rearrangement cascade reaction was discovered for the synthesis of indoline-piperidinones in one pot. A series of targeted compounds was prepared by means of a mild reaction and a simple operation procedure, which could be applicable to a broad scope of Ugi starting materials. This cascade reaction generates opportunities for the tailored synthesis of a wide range of indoline-piperidinone scaffolds through tuneable Ugi inputs.

中文翻译：

通过新型Ugi，环扩环，拟狄克曼缩合和重排级联反应合成吲哚啉-哌啶酮

发现一种Ugi环扩环，拟Dieckmann缩合和重排级联反应可在一锅中合成二氢吲哚-哌啶酮。通过温和的反应和简单的操作步骤制备了一系列目标化合物，这些化合物可能适用于广泛的Ugi起始原料。这种级联反应为通过可调节的Ugi输入量身定制各种吲哚啉-哌啶酮骨架的合成提供了机会。

更新日期：2020-03-03

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