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Integrating microfluidics and biosensing on a single flexible acoustic device using hybrid modes.
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-03-03 , DOI: 10.1039/c9lc01189g
Ran Tao 1 , Julien Reboud 2 , Hamdi Torun 3 , Glen McHale 3 , Linzi E Dodd 3 , Qiang Wu 3 , Kai Tao 4 , Xin Yang 5 , Jing Ting Luo 6 , Stephen Todryk 7 , Yongqing Fu 3
Affiliation  

Integration of microfluidics and biosensing functionalities on a single device holds promise in continuous health monitoring and disease diagnosis for point-of-care applications. However, the required functions of fluid handling and biomolecular sensing usually arise from different actuation mechanisms. In this work, we demonstrate that a single acoustofluidic device, based on a flexible thin film platform, is able to generate hybrid wave modes, which can be used for fluidic actuation (Lamb waves) and biosensing (thickness shear waves). On this integrated platform, we show multiple and sequential functions of mixing, transport and disposal of liquid volumes using Lamb waves, whilst the thickness bulk shear waves allow us to sense the chemotherapeutic Imatinib, using an aptamer-based strategy, as would be required for therapy monitoring. Upon binding, the conformation of the aptamer results in a change in coupled mass, which has been detected. This platform architecture has the potential to generate a wide range of simple sample-to-answer biosensing acoustofluidic devices.

中文翻译:

使用混合模式在单个柔性声学设备上集成微流体和生物传感。

在单个设备上集成微流控和生物传感功能有望为即时医疗应用提供持续的健康监测和疾病诊断。然而,流体处理和生物分子传感所需的功能通常来自不同的驱动机制。在这项工作中,我们证明了基于柔性薄膜平台的单个声流体装置能够产生混合波模式,可用于流体驱动(Lamb 波)和生物传感(厚度剪切波)。在这个集成平台上,我们展示了使用 Lamb 波混合、运输和处理液体体积的多种顺序功能,而厚度体剪切波使我们能够使用基于适体的策略来感知化疗伊马替尼,这将是治疗监测。结合后,适体的构象导致耦合质量发生变化,这已被检测到。这种平台架构有可能生成各种简单的样本到答案的生物传感声流控设备。
更新日期:2020-03-03
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