Compact reaction-module on a pad for scalable flow-production of organophosphates as drug scaffolds.,Lab on a Chip

当前位置： X-MOL 学术 › Lab Chip › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Compact reaction-module on a pad for scalable flow-production of organophosphates as drug scaffolds.
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-03-03 , DOI: 10.1039/c9lc01099h
Se Jun Yim ₁ , Bandaru T Ramanjaneyulu ₁ , Shinde Vidyacharan ₁ , Yu Dong Yang ₂ , In Seok Kang ₂ , Dong-Pyo Kim ₁

Affiliation

Continuous pharmaceutical manufacturing receives intense attention as an alternative way to meet flexible market needs with the assurance of higher safety and quality control. Here, we report a compact reaction-module on a pad (CRP, 170 × 170 × 1.2 mm) for scale-up production of drug precursors in a continuous-flow. The CRP system was devised by stacking 9 films of the patterned polyimide to integrate micro-flow circuits, combining the functions of the even distribution of feeds, being completely mixed in less than a few milliseconds. A methodology of using a highly reactive species for the single-step synthesis of α-phosphonyloxy ketone, a drug scaffold, required the synthesis time of a few seconds in microfluidics. The fast reaction in the single CRP was capable of producing 19.2 g h-1 drug precursor, which indicates a solid step toward kilogram-scale pharmaceutical manufacturing in small footage.

中文翻译：

垫上的紧凑型反应模块，可扩展生产作为药物支架的有机磷酸酯。

连续制药业作为一种满足灵活市场需求的替代方法而受到了广泛关注，并保证了更高的安全性和质量控制。在这里，我们报告了在垫上的紧凑反应模块（CRP，170×170×1.2 mm），用于按连续流放大生产药物前体。通过堆叠9片图案化的聚酰亚胺薄膜来设计CRP系统，以集成微流回路，结合了进料均匀分布的功能，并在不到几毫秒的时间内完成了完全混合。使用高反应性物质进行药物支架α-膦酰氧基酮的一步合成的方法在微流控中需要几秒钟的合成时间。单个CRP中的快速反应能够产生19.2 g h-1药物前体，

更新日期：2020-03-03

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11