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Transition metal- and solvent-free double hydroboration of nitriles
Green Chemistry ( IF 9.3 ) Pub Date : 2020/01/29 , DOI: 10.1039/c9gc04260a Deepika Bedi 1, 2, 3, 4 , Aneelman Brar 1, 2, 3, 4 , Michael Findlater 1, 2, 3, 4
Green Chemistry ( IF 9.3 ) Pub Date : 2020/01/29 , DOI: 10.1039/c9gc04260a Deepika Bedi 1, 2, 3, 4 , Aneelman Brar 1, 2, 3, 4 , Michael Findlater 1, 2, 3, 4
Affiliation
A highly efficient, room temperature double hydroboration of nitriles under transition metal-free and solvent-free conditions is reported. Sodium triethylborohydride is used as a catalyst and yields up to 99% are disclosed. Mechanistic studies reveal the reaction proceeds in a stepwise manner with initial formation of a boryl-imine which undergoes a second hydroboration to afford a diborylated amine product.
中文翻译:
不含过渡金属和溶剂的腈双硼氢化
据报道,在无过渡金属和无溶剂的条件下,腈可进行高效的室温双硼氢化。三乙基硼氢化钠被用作催化剂,并且公开了产率高达99%。机理研究表明,该反应以逐步形成的方式进行,首先形成了硼烷基-亚胺,该硼烷基-亚胺经过第二次氢硼化生成了二硼化的胺产物。
更新日期:2020-02-24
中文翻译:
不含过渡金属和溶剂的腈双硼氢化
据报道,在无过渡金属和无溶剂的条件下,腈可进行高效的室温双硼氢化。三乙基硼氢化钠被用作催化剂,并且公开了产率高达99%。机理研究表明,该反应以逐步形成的方式进行,首先形成了硼烷基-亚胺,该硼烷基-亚胺经过第二次氢硼化生成了二硼化的胺产物。