Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain.
Analyst ( IF 3.6 ) Pub Date : 2020/02/07 , DOI: 10.1039/c9an02270h W X Wang 1 , S N Whitehead
Analyst ( IF 3.6 ) Pub Date : 2020/02/07 , DOI: 10.1039/c9an02270h W X Wang 1 , S N Whitehead
Affiliation
|
Gangliosides have a wide variety of biological functions due to their location on the outer leaflet of plasma membranes. They form a critical component of membrane rafts, or ganglioside-enriched microdomains, where they influence the physical properties of the membrane as well as its function. Gangliosides can change their structure to meet their external and internal environmental demands. This ability to change structure makes gangliosides both fascinating and technologically challenging targets to identify and understand. A full understanding on how gangliosides are regulated within the central nervous system (CNS) is critical, as ganglioside dysregulation is observed in the aging brain as well as in several neurodegenerative injuries and diseases such as stroke, Alzheimer's disease, Parkinson's disease, Huntington's disease and several lysosomal storage disorders diseases, including Tay Sach's disease. Mass spectrometry (MS) has become a useful means to better understand ganglioside composition and function. Imaging mass spectrometry (IMS) provides the added benefit of placing analytical information within an anatomical context. This review article will discuss recent advances in MS-based detection methods, with a focus on IMS-based approaches to help understand the spatial-specific role gangliosides in the healthy brain as in CNS injuries and disease.
中文翻译：
成像质谱可以在健康和患病的大脑中对神经节苷脂进行神经解剖学特异性检测。
神经节苷脂由于位于质膜的外部小叶上而具有多种生物学功能。它们形成了膜筏或富含神经节苷脂的微区的关键组成部分，它们在其中影响膜的物理性质及其功能。神经节苷脂可以改变其结构以满足其内部和外部环境需求。这种改变结构的能力使神经节苷脂既令人着迷，又具有技术挑战性，难以识别和理解。对神经节苷脂在中枢神经系统（CNS）中如何进行调节的全面了解至关重要，因为在衰老的大脑以及一些神经退行性损伤和疾病（例如中风，阿尔茨海默氏病，帕金森氏病，亨廷顿病）中都观察到神经节苷脂失调。氏病和几种溶酶体贮积失调疾病，包括泰克氏病。质谱（MS）已成为更好地了解神经节苷脂的组成和功能的有用手段。成像质谱（IMS）提供了将分析信息放在解剖环境中的附加好处。本文将讨论基于MS的检测方法的最新进展，重点是基于IMS的方法，以帮助理解神经节苷脂在健康大脑中的中枢神经系统损伤和疾病的空间特异性作用。
更新日期：2020-03-31
中文翻译：
成像质谱可以在健康和患病的大脑中对神经节苷脂进行神经解剖学特异性检测。
神经节苷脂由于位于质膜的外部小叶上而具有多种生物学功能。它们形成了膜筏或富含神经节苷脂的微区的关键组成部分，它们在其中影响膜的物理性质及其功能。神经节苷脂可以改变其结构以满足其内部和外部环境需求。这种改变结构的能力使神经节苷脂既令人着迷，又具有技术挑战性，难以识别和理解。对神经节苷脂在中枢神经系统（CNS）中如何进行调节的全面了解至关重要，因为在衰老的大脑以及一些神经退行性损伤和疾病（例如中风，阿尔茨海默氏病，帕金森氏病，亨廷顿病）中都观察到神经节苷脂失调。氏病和几种溶酶体贮积失调疾病，包括泰克氏病。质谱（MS）已成为更好地了解神经节苷脂的组成和功能的有用手段。成像质谱（IMS）提供了将分析信息放在解剖环境中的附加好处。本文将讨论基于MS的检测方法的最新进展，重点是基于IMS的方法，以帮助理解神经节苷脂在健康大脑中的中枢神经系统损伤和疾病的空间特异性作用。
京公网安备 11010802027423号