A novel nanoarchitecture (MSN-Tb-UbR) was prepared by modifying rhodamine B-labelled Ubs (Ub-Rs) on the surface of mesoporous silica nanoparticles (MSNs) loaded with Tb3+-complexes. The MSN-Tb-UbR exhibits ratiometric sensing ability for DUB (UCH-L1) with good sensitivity and selectivity.

中文翻译：

---

基于荧光共振能量转移（FRET）的纳米体系结构，用于监测去泛素化酶的活性。

通过修饰负载了Tb3 +复合物的中孔二氧化硅纳米粒子（MSN）表面上的若丹明B标记的Ub（Ub-Rs），制备了一种新型的纳米结构（MSN-Tb-UbR）。MSN-Tb-UbR具有对DUB（UCH-L1）的比例感测能力，具有良好的灵敏度和选择性。