Association of phthalate exposure with precocious and delayed pubertal timing in girls and boys: a systematic review and meta-analysis.,Environmental Science: Processes & Impacts

当前位置： X-MOL 学术 › Environ. Sci.: Processes Impacts › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Association of phthalate exposure with precocious and delayed pubertal timing in girls and boys: a systematic review and meta-analysis.
Environmental Science: Processes & Impacts ( IF 4.3 ) Pub Date : 2020-04-29 , DOI: 10.1039/c9em00512a
Mohsen Golestanzadeh ₁ , Roya Riahi , Roya Kelishadi

Affiliation

Exposure to phthalate derivatives has adverse effects on the health and development of humans, especially for children. A growing body of evidence supports the idea that exposure to phthalates can change an individual's physiological set point and the time of puberty in both genders. In this systematic review and meta-analysis, recent studies were evaluated to obtain systematic and regulation results in relation to puberty status and phthalate exposure in girls and boys. We searched English-language papers using Scopus, ISI, and PubMed databases as search engines, with no restriction of time, until the end of July 2019. A comprehensive literature search for an association between phthalate exposure and signs of puberty as well as levels of different types of hormones was carefully performed. Of the 67 studies retained for full-text screening, 39 studies were eligible for data management and extraction. For conducting a meta-analysis, four studies had appropriate effect size and metrics for pooling in the meta-analysis. Our findings revealed that low and high exposure to phthalates could alter pubertal development in both genders; the effects were either early or delayed puberty such as changes in the pubarche, thelarche, and menarche time, as well as in testicular volume. We statistically analyzed the association of pubic-hair development, breast development, and menarche time with exposure to phthalates in girls. For example, the pooled odds ratios of mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) in relation to breast development were (OR: 1.48, 95% CI: 1.11-1.85) and (OR: 1.52, 95% CI: 1.15-1.58) (P-value < 0.001), respectively. In addition, we analyzed the correlation between pubic-hair development and testicular volume with exposure to phthalates in boys. To the best of our knowledge, this is the first systematic review and meta-analysis of its kind for girls and boys. In conclusion, we found that a positive association exists between phthalate exposure and pubertal timing in the pediatric age group. Therefore, prevention of exposure to phthalates and reduction of their use should be underscored in the strategies for primordial prevention of pubertal timing and related consequences.

中文翻译：

邻苯二甲酸酯暴露与男孩和女孩早熟和延迟青春期的关联：系统评价和荟萃分析。

邻苯二甲酸盐衍生物的暴露会对人类尤其是儿童的健康和发育产生不利影响。越来越多的证据支持这样的观点，即邻苯二甲酸盐的暴露可以改变一个人的生理学设定点和两个性别的青春期。在这项系统的回顾和荟萃分析中，对近期的研究进行了评估，以获取有关青春期状态和男孩和女孩邻苯二甲酸酯暴露的系统性和调节性结果。我们使用Scopus，ISI和PubMed数据库作为搜索引擎来搜索英语论文，并且没有时间限制，直到2019年7月底。全面的文献搜索了邻苯二甲酸酯暴露与青春期体征以及肥胖水平之间的关联。仔细进行了不同类型的激素。在保留用于全文筛选的67项研究中，39项研究符合数据管理和提取的条件。为了进行荟萃分析，四项研究具有适当的效应量和指标，可用于荟萃分析。我们的研究结果表明，低和高暴露于邻苯二甲酸盐可能会改变男女的青春期发育。其影响是青春期的早期或延迟，例如青春期，睾丸和初潮时间以及睾丸体积的变化。我们从统计学角度分析了女孩的阴毛发育，乳房发育和初潮时间与邻苯二甲酸酯暴露的关系。例如，邻苯二甲酸单（2-乙基-5-羟己基）酯（MEHHP）和邻苯二甲酸单（2-乙基-5-氧己基）（MEOHP）的合并优势比为（OR：1.48，95％ CI：1.11-1.85）和（OR：1.52，95％CI：1.15-1.58）（P值<0.001）。此外，我们分析了男孩的阴毛发育与睾丸体积与邻苯二甲酸酯暴露之间的相关性。据我们所知，这是首次对男孩和女孩进行系统的系统评价和荟萃分析。总之，我们发现小儿年龄组的邻苯二甲酸酯暴露与青春期时机之间存在正相关。因此，在初步预防青春期时机和相关后果的策略中应强调预防邻苯二甲酸盐的接触和减少其使用。我们发现，小儿年龄组的邻苯二甲酸酯暴露与青春期时机之间存在正相关。因此，在初步预防青春期时机和相关后果的策略中应强调预防邻苯二甲酸盐的接触和减少其使用。我们发现，小儿年龄组的邻苯二甲酸酯暴露与青春期时机之间存在正相关。因此，在初步预防青春期时机和相关后果的策略中应强调预防邻苯二甲酸盐的接触和减少其使用。

更新日期：2020-01-27

点击分享查看原文

点击收藏

阅读更多本刊最新论文