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Tumor-targeting multi-shelled hollow nanospheres as drug loading platforms for imaging-guided combinational cancer therapy.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-01-31 , DOI: 10.1039/c9bm01881f Wentao Wang 1 , Tao Zheng 1 , Ming Zhang 2 , Qicheng Zhang 3 , Fan Wu 3 , Yihan Liu 3 , Lin Zhang 4 , Jun Zhang 3 , Mingqian Wang 5 , Yi Sun 1
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-01-31 , DOI: 10.1039/c9bm01881f Wentao Wang 1 , Tao Zheng 1 , Ming Zhang 2 , Qicheng Zhang 3 , Fan Wu 3 , Yihan Liu 3 , Lin Zhang 4 , Jun Zhang 3 , Mingqian Wang 5 , Yi Sun 1
Affiliation
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In this work, we developed multi-shelled hollow nanospheres [RGD@am-ZnO@CuO@Au@DOX HNSs] as multifunctional therapeutic agents to achieve effective and targeted Zn2+/Cu2+ therapy, induced drug delivery under low pH/red-light conditions, and enhanced phototherapy under single red-light. The photothermal and photodynamic performance of am-ZnO@CuO@Au HNSs was enhanced relative to that of am-ZnO nanoparticles (NPs) or am-ZnO@CuO HNSs by utilizing the resonance energy transfer process and broad red-light absorption. The pH-sensitive am-ZnO@CuO@Au HNSs were dissolved to Zn2+/Cu2+ in the acidic endosomes/lysosomes of cancer cells, resulting in a cancer cell killing effect. The release performance of doxorubicin (DOX) from RGD@am-ZnO@CuO@Au@DOX HNSs was evaluated under low pH and red-light-irradiated conditions, and targeting of HNSs was confirmed by dual-modal imaging (magnetic resonance/fluorescence) of the tumor area. Moreover, in vivo synergistic therapy using RGD@am-ZnO@CuO@Au@DOX HNSs was further evaluated in mice bearing human pulmonary adenocarcinoma (A549) cells, achieving a remarkable synergistic antitumor effect superior to that obtained by monotherapy. This study validated that RGD@am-ZnO@CuO@Au@DOX HNSs can be a promising candidate for efficient postoperative cancer therapy.
中文翻译：
靶向肿瘤的多壳空心纳米球作为成像引导联合癌症治疗的药物加载平台。
在这项工作中，我们开发了多壳空心纳米球[RGD @ am-ZnO @ CuO @ Au @ DOX HNSs]作为多功能治疗剂，以实现有效和靶向的Zn2 + / Cu2 +治疗，在低pH /红光条件下诱导药物递送，并在单红光下增强光疗。相对于am-ZnO纳米粒子（NPs）或am-ZnO @ CuO HNS的共振能量转移过程和广泛的红光吸收，am-ZnO @ CuO @ Au HNS的光热和光动力性能得到了增强。pH敏感的am-ZnO @ CuO @ Au HNS在癌细胞的酸性内体/溶酶体中溶解为Zn2 + / Cu2 +，从而具有杀死癌细胞的作用。在低pH和红光照射条件下评估了RGD @ am-ZnO @ CuO @ Au @ DOX HNS中阿霉素（DOX）的释放性能，HNSs的靶向性已通过肿瘤区域的双模式成像（磁共振/荧光）得以证实。此外，在带有人肺腺癌（A549）细胞的小鼠中，进一步评估了使用RGD @ am-ZnO @ CuO @ Au @ DOX HNS的体内协同治疗，获得了明显优于单一疗法的协同抗肿瘤效果。这项研究证实，RGD @ am-ZnO @ CuO @ Au @ DOX HNS可以成为有效的术后癌症治疗的有希望的候选人。
更新日期：2020-03-19
中文翻译：
靶向肿瘤的多壳空心纳米球作为成像引导联合癌症治疗的药物加载平台。
在这项工作中，我们开发了多壳空心纳米球[RGD @ am-ZnO @ CuO @ Au @ DOX HNSs]作为多功能治疗剂，以实现有效和靶向的Zn2 + / Cu2 +治疗，在低pH /红光条件下诱导药物递送，并在单红光下增强光疗。相对于am-ZnO纳米粒子（NPs）或am-ZnO @ CuO HNS的共振能量转移过程和广泛的红光吸收，am-ZnO @ CuO @ Au HNS的光热和光动力性能得到了增强。pH敏感的am-ZnO @ CuO @ Au HNS在癌细胞的酸性内体/溶酶体中溶解为Zn2 + / Cu2 +，从而具有杀死癌细胞的作用。在低pH和红光照射条件下评估了RGD @ am-ZnO @ CuO @ Au @ DOX HNS中阿霉素（DOX）的释放性能，HNSs的靶向性已通过肿瘤区域的双模式成像（磁共振/荧光）得以证实。此外，在带有人肺腺癌（A549）细胞的小鼠中，进一步评估了使用RGD @ am-ZnO @ CuO @ Au @ DOX HNS的体内协同治疗，获得了明显优于单一疗法的协同抗肿瘤效果。这项研究证实，RGD @ am-ZnO @ CuO @ Au @ DOX HNS可以成为有效的术后癌症治疗的有希望的候选人。
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