Haloacid dehalogenases catalyse the cleavage of carbon − halogen bonds in halogenated organic acids. These enzymes are of high interest due to their potential applications in bioremediation and in synthesis of various industrial products. The efficiency of dehalogenases in various applications can be enhanced, provided that their molecular catalytic mechanisms are fully understood. Herein, we review the current understanding of enzymatic haloacid dehalogenation mechanisms and the important amino acid residues that are necessary for the enzyme’s catalysis, with special emphasis on haloacid dehalogenases produced by Rhizobium sp.

中文翻译：

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根瘤菌的卤酸脱卤酶。和相关酶：催化性能和机理分析

卤酸脱卤酶催化卤化有机酸中碳-卤键的断裂。这些酶因其在生物修复和各种工业产品合成中的潜在应用而备受关注。只要充分了解脱卤酶的分子催化机制，就可以提高其在各种应用中的效率。在此，我们回顾了目前对酶促卤酸脱卤机制的理解以及酶催化所必需的重要氨基酸残基，特别强调了由根瘤菌产生的卤酸脱卤酶。