The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens.,European Journal of Medicinal Chemistry

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The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens.
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2020-02-08 , DOI: 10.1016/j.ejmech.2020.112132
Silvia Buroni ₁ , Vadim Makarov ₂ , Viola Camilla Scoffone ₁ , Gabriele Trespidi ₁ , Giovanna Riccardi ₁ , Laurent R Chiarelli ₁

Affiliation

Cystic fibrosis is a rare genetic disease characterized by the production of dehydrated mucus in the lung able to trap bacteria and rendering their proliferation particularly dangerous, thus leading to chronic infections. Among these bacteria, Staphylococcus aureus and Pseudomonas aeruginosa play a major role while, within emerging pathogens, Stenotrophomonas maltophilia, Achromobacter xylosoxidans, Burkholderia cepacia complex species, as well as non-tuberculous mycobacteria are listed. Since a common feature of these bacteria is the high level of drug resistance, cell division, and in particular FtsZ, has been explored as a novel therapeutic target for the design of new molecules with antibacterial properties. This review summarizes and provides insight into recent advances in the discovery of compounds targeting FtsZ: the majority of them exhibit anti-staphylococcal activity, while a few were directed against the cystic fibrosis Gram negative pathogens.

中文翻译：

细胞分裂蛋白FtsZ作为击中囊性纤维化病原体的细胞靶标。

囊性纤维化是一种罕见的遗传疾病，其特征是在肺部产生脱水的粘液，能够捕获细菌并使其扩散特别危险，从而导致慢性感染。在这些细菌中，金黄色葡萄球菌和铜绿假单胞菌起主要作用，而在新兴病原体中，嗜麦芽窄食单胞菌，木糖氧化无色杆菌，洋葱伯克霍尔德菌复杂物种以及非结核分枝杆菌被列出。由于这些细菌的共同特征是高水平的耐药性，因此已经探索了细胞分裂，尤其是FtsZ，作为设计具有抗菌特性的新分子的新型治疗靶标。这篇综述总结并提供了针对FtsZ的化合物发现方面的最新进展的见解：

更新日期：2020-02-10

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