Serine-glycine-one-carbon metabolism: vulnerabilities in MYCN-amplified neuroblastoma.,Oncogenesis

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Serine-glycine-one-carbon metabolism: vulnerabilities in MYCN-amplified neuroblastoma.
Oncogenesis ( IF 5.9 ) Pub Date : 2020-02-07 , DOI: 10.1038/s41389-020-0200-9
Erhu Zhao _{1,

2,

3,

4} , Jianbing Hou _{1,

2,

3,

4} , Hongjuan Cui _{1,

2,

3,

4}

Affiliation

In a recent study published in Cancer Research, Xia and colleagues reported that, in cancer, constituents in serine-glycine-one-carbon (SGOC) metabolism exhibit enhanced transcriptional activation and are increasingly utilised, which results in more glucose-derived carbon to serine-glycine biosynthesis. The current work identifies an MYCN-dependent metabolic vulnerability and shows a variety of associations between metabolic reprogramming and enhanced sensitivity to metabolic stress, which may lead the way to unlocking new anticancer therapies. Here, we summarised new insights into the role of SGOC metabolism in the progression of neuroblastoma (NB) with highly activated SGOC metabolism.

中文翻译：

丝氨酸-甘氨酸一碳代谢：MYCN扩增的神经母细胞瘤中的脆弱性。

Xia及其同事在《癌症研究》上发表的最新研究中报告说，在癌症中，丝氨酸-甘氨酸一碳（SGOC）代谢中的成分表现出增强的转录激活并得到越来越多的利用，从而导致更多的葡萄糖衍生的碳生成丝氨酸。 -甘氨酸的生物合成。当前的工作确定了依赖MYCN的代谢脆弱性，并显示了代谢重编程与对代谢应激的增强敏感性之间的各种关联，这可能会为解锁新的抗癌疗法提供途径。在这里，我们总结了SGOC代谢在具有高度激活的SGOC代谢的神经母细胞瘤（NB）进程中的作用的新见解。

更新日期：2020-02-07

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