Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice.,European Journal of Immunology

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Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-03-01 , DOI: 10.1002/eji.201948354
Giuseppina D'Alessandro _{1,

2} , Fabrizio Antonangeli ₃ , Francesco Marrocco _{1,

4} , Alessandra Porzia ₃ , Clotilde Lauro ₁ , Angela Santoni _{2,

3} , Cristina Limatola _{2,

5}

Affiliation

Glioma is a CNS tumor with few therapeutic options. Recently, host microbiota has been involved in the immune modulation of different tumors, but no data are available on the possible effects of the gut-immune axis on brain tumors. Here, we investigated the effect of gut microbiota alteration in a syngeneic (GL261) mouse model of glioma, treating mice with two antibiotics (ABX) and evaluating the effects on tumor growth, microbe composition, natural killer (NK) cells and microglia phenotype. We report that ABX treatment (i) altered the intestinal microbiota at family level, (ii) reduced cytotoxic NK cell subsets, and (iii) altered the expression of inflammatory and homeostatic proteins in microglia. All these findings could contribute to the increased growth of intracranial glioma that was observed after ABX treatment. These results demonstrate that chronic ABX administration alters microbiota composition and contributes to modulate brain immune state paving the way to glioma growth.

中文翻译：

肠道菌群的改变会影响神经胶质瘤的生长和参与小鼠肿瘤免疫监测的先天免疫细胞。

胶质瘤是中枢神经系统肿瘤，几乎没有治疗选择。最近，宿主菌群已经参与了不同肿瘤的免疫调节，但是尚无关于肠道免疫轴对脑肿瘤可能作用的数据。在这里，我们调查了胶质瘤的同系（GL261）小鼠模型中肠道菌群改变的影响，用两种抗生素（ABX）处理小鼠，并评估了对肿瘤生长，微生物组成，自然杀伤（NK）细胞和小胶质细胞表型的影响。我们报告ABX治疗（i）在家庭水平上改变了肠道菌群，（ii）减少了细胞毒性NK细胞亚群，并且（iii）改变了小胶质细胞中炎性和稳态蛋白的表达。所有这些发现可能有助于ABX治疗后观察到的颅内神经胶质瘤生长的增加。

更新日期：2020-03-01

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