Parametric response mapping (PRM) is a novel computed tomography (CT) technology that has shown potential for assessment of bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HCT). The primary aim of this study was to evaluate whether variations in image acquisition under real‐world conditions affect the PRM measurements of clinically diagnosed BOS. CT scans were obtained retrospectively from 72 HCT recipients with BOS and graft‐versus‐host disease from Fred Hutchinson Cancer Research Center, Karolinska Institute, and the University of Michigan. Whole lung volumetric scans were performed at inspiration and expiration using site‐specific acquisition and reconstruction protocols. PRM and pulmonary function measurements were assessed. Patients with moderately severe BOS at diagnosis (median forced expiratory volume at 1 second [FEV1] 53.5% predicted) had similar characteristics between sites. Variations in site‐specific CT acquisition protocols had a negligible effect on the PRM‐derived small airways disease (SAD), that is, BOS measurements. PRM‐derived SAD was found to correlate with FEV1% predicted and FEV1/ forced vital capacity (R  = −0.236, P  = .046; and R  = −0.689, P  < .0001, respectively), which suggests that elevated levels in the PRM measurements are primarily affected by BOS airflow obstruction and not CT scan acquisition parameters. Based on these results, PRM may be applied broadly for post‐HCT diagnosis and monitoring of BOS.

中文翻译：

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参数反应图的多中心评价作为造血干细胞移植后闭塞性细支气管炎综合征的指标。

参数反应映射 (PRM) 是一种新型计算机断层扫描 (CT) 技术，已显示出评估造血干细胞移植 (HCT) 后闭塞性细支气管炎综合征 (BOS) 的潜力。本研究的主要目的是评估真实世界条件下图像采集的变化是否影响临床诊断 BOS 的 PRM 测量。从 Fred Hutchinson 癌症研究中心、卡罗林斯卡研究所和密歇根大学的 72 名患有 BOS 和移植物抗宿主病的 HCT 接受者中回顾性地获得了 CT 扫描。使用特定部位的采集和重建协议在吸气和呼气时进行全肺容积扫描。评估了 PRM 和肺功能测量值。诊断时患有中度重度 BOS 的患者（第 1 秒用力呼气量中位数 [FEV1] 预测值为 53.5%）在不同地点之间具有相似的特征。特定部位 CT 采集协议的变化对 PRM 衍生的小气道疾病 (SAD)，即 BOS 测量的影响可以忽略不计。发现 PRM 衍生的 SAD 与 FEV1% 预测值和 FEV1/用力肺活量相关（R  = −0.236，P  = .046；和R  = −0.689，P  < .0001），这表明 PRM 测量值升高主要受 BOS 气流阻塞的影响，而不是 CT 扫描采集参数。基于这些结果，PRM 可广泛应用于 HCT 后 BOS 的诊断和监测。