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Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy
Allergy ( IF 12.6 ) Pub Date : 2020-03-09 , DOI: 10.1111/all.14222
Rasmus K Jensen 1 , Frederic Jabs 2 , Michaela Miehe 2 , Brian Mølgaard 2 , Wolfgang Pfützner 3 , Christian Möbs 3 , Edzard Spillner 2 , Gregers R Andersen 1
Affiliation  

IgE is the central antibody isotype in TH2‐biased immunity and allergic diseases. The structure of intact IgE and the impact of IgE‐targeting molecules on IgE however remain elusive. In order to obtain insights into IgE biology and the clinical impact, we aimed for structure determination of IgE and the complex of IgE with the anti‐IgE antibody ligelizumab.

中文翻译:

电子显微镜揭示完整 IgE 的结构和 ligelizumab 的作用机制

IgE 是 TH2 偏向免疫和过敏性疾病的中心抗体同种型。然而,完整 IgE 的结构和 IgE 靶向分子对 IgE 的影响仍然难以捉摸。为了深入了解 IgE 生物学和临床影响,我们旨在确定 IgE 的结构以及 IgE 与抗 IgE 抗体 ligelizumab 的复合物。
更新日期:2020-03-09
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