Paternal Folate Status and Sperm Quality, Pregnancy Outcomes, and Epigenetics: A Systematic Review and Meta-Analysis.,Molecular Nutrition & Food Research

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Paternal Folate Status and Sperm Quality, Pregnancy Outcomes, and Epigenetics: A Systematic Review and Meta-Analysis.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-02-20 , DOI: 10.1002/mnfr.201900696
Jeffrey Hoek ₁ , Régine P M Steegers-Theunissen ₁ , Sten P Willemsen _{1,

2} , Sam Schoenmakers ₁

Affiliation

The effectiveness of maternal folate in reducing the risk of congenital malformations during pregnancy is well established. However, the role of the paternal folate status is scarcely investigated. The aim of this study is to investigate the evidence of associations between the paternal folate status and sperm quality, sperm epigenome, and pregnancy outcomes.

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