In this review we highlighted the newest aspects concerning the physiopathology of breast cancer metastatization into the bone including: a) in situ biomarkers of breast cancer metastatic diseases, b) biological processes related to the origin of metastatic cells (epithelial to mesenchymal transition), c) the nature and the possible role of Breast Osteoblast-Like Cells in the formation of bone lesions and d) the prognostic value of breast microcalcifications for the bone metastatic disease.

In addition, the more recent data about the biology of breast cancer metastatic process and the origin and function of Breast Osteoblast-Like Cells have been analyzed to propose the use of molecular imaging investigations able to identify early neoplastic lesions with high propensity to form bone metastasis in vivo.

在这篇综述中，我们重点介绍了有关乳腺癌骨转移的生理病理学的最新方面，包括：a)乳腺癌转移性疾病的原位生物标志物，b) 与转移细胞起源相关的生物学过程（上皮到间质转化），c ) 乳腺成骨细胞样细胞在骨病变形成中的性质和可能的作用和 d) 乳腺微钙化对骨转移性疾病的预后价值。

此外，分析了有关乳腺癌转移过程的生物学以及乳腺成骨细胞样细胞的起源和功能的最新数据，以提出使用分子成像研究能够识别具有高形成骨转移倾向的早期肿瘤性病变在体内。