Modular Approach to the Functionalization of Polymersomes.,Biomacromolecules

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Modular Approach to the Functionalization of Polymersomes.
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-02-19 , DOI: 10.1021/acs.biomac.9b01734
Sjoerd J Rijpkema ₁ , Sabine G H A Langens ₁ , Marnix R van der Kolk ₁ , Katerina Gavriel ₁ , B Jelle Toebes ₁ , Daniela A Wilson ₁

Affiliation

Functionalizing polymersomes remains a challenge due to the limitation in reaction conditions applicable to the chemistry on the surface, hindering their application for selective targeting. In order to overcome this limitation, functionalization can be introduced right before the self-assembly. Here, we have synthesized a library (32 examples) of PEG-b-PS and PEG-b-PDLLA with various functional groups derived from the amine-functionalized polymers, leading to functionally active polymersomes. We show that polymersome formation is possible via the general method with all functionalized groups and that these handles are present on the surface and are able to undergo reactions. Additionally, this methodology provides a general synthetic tool to tailor the functional group of the polymersome right before self-assembly, without limitation on the reaction conditions.

中文翻译：

聚合物囊泡功能化的模块化方法。

由于适用于表面化学的反应条件的限制，功能化聚合物囊泡仍然是一个挑战，阻碍了它们在选择性靶向方面的应用。为了克服这一限制，可以在自组装之前引入功能化。在这里，我们合成了 PEG-b-PS 和 PEG-b-PDLLA 的库（32 个实例），其具有源自胺官能化聚合物的各种官能团，从而形成具有功能活性的聚合物囊泡。我们表明，通过通用方法，所有官能团都可以形成聚合物囊泡，并且这些手柄存在于表面上并且能够进行反应。此外，该方法提供了一种通用合成工具，可以在自组装之前定制聚合物囊泡的官能团，而不受反应条件的限制。

更新日期：2020-02-07

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