Phototheranostic agents are capable of both therapeutic and diagnostic potential, making them a promising strategy for cancer therapy. BODIPY is an outstanding photosensitizer for Photodynamic Therapy (PDT). Here we engineered a BODIPY-based phototheranostic nanoparticle with photo-chemo synergistic property and the nanoparticle [email protected] (MGBP) possesses excellent ROS production ability, high photothermal conversion efficiency (48%), and excellent therapy efficiency (HeLa cell viability was down to 17% after treatment) in vitro. Furthermore, because of its high fluorescence and anti-photobleaching ability of BODIPY and photothermal conversion ability of Graphene, MGBP showed superior fluorescence and photothermal imaging ability in the agar model. In summary, MGBP possessed the excellent potential for tumour tissue imaging-guided photo-chemo synergistic therapy.

光热疗剂具有治疗和诊断潜力，使其成为一种有前途的癌症治疗策略。BODIPY是用于光动力疗法（PDT）的杰出光敏剂。在这里，我们设计了一种具有光化学协同性能的基于BODIPY的光热敏纳米颗粒，该纳米颗粒[email protected]（MGBP）具有出色的ROS生产能力，高的光热转化效率（48％）和出色的治疗效率（HeLa细胞活力下降）到处理后的17％）在体外。此外，由于其高的荧光和BODIPY的抗光漂白能力以及石墨烯的光热转化能力，MGBP在琼脂模型中显示出优异的荧光和光热成像能力。总之，MGBP在肿瘤组织成像指导的光化学协同治疗中具有极好的潜力。