Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are members of the genus Roseolovirus in the Betaherpesvirinae subfamily. HHV-6B infects humans in the first years of life, has a seroprevalence of more than 90% and causes Roseola Infantum, but less is known about HHV-6A. While most other herpesviruses maintain their latent genome as a circular episome, HHV-6A and HHV-6B (HHV-6A/B) have been shown to integrate their genome into the telomeres of infected cells. HHV-6A/B can also integrate into the chromosomes of germ cells, resulting in individuals carrying a copy of the virus genome in every nucleated cell of their bodies. This review highlights our current understanding of HHV-6A/B integration and reactivation as well as aspects that should be addressed in the future of this relatively young research area. It forms part of an online symposium on the prevention and therapy of DNA virus infections, dedicated to the memory of Mark Prichard.

中文翻译：

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对人类疱疹病毒6（HHV-6）染色体整合的当前了解。

人疱疹病毒6A（HHV-6A）和6B（HHV-6B）是Betaherpesvirinae亚科中的迷迭香病毒属的成员。HHV-6B在生命的最初几年会感染人类，其血清阳性率超过90％，并引起Roseola Infantum，但对HHV-6A的了解却很少。尽管大多数其他疱疹病毒维持其潜在基因组为环状附加体，但已显示HHV-6A和HHV-6B（HHV-6A / B）将其基因组整合到受感染细胞的端粒中。HHV-6A / B还可以整合到生殖细胞的染色体中，从而导致个体在其身体的每个有核细胞中携带病毒基因组的副本。这篇综述强调了我们对HHV-6A / B整合和再激活的当前理解，以及在这个相对年轻的研究领域的未来应解决的方面。