Intrinsically disordered protein regions are at the core of biological processes and involved in key protein-ligand interactions. The Flavivirus proteins, of viruses of great biomedical importance such as Zika and dengue viruses, exemplify this. Several proteins of these viruses have disordered regions that are of the utmost importance for biological activity. Disordered proteins can adopt several conformations, each able to interact with and/or bind to different ligands. In fact, such interactions can help stabilize a particular fold. Moreover, by being promiscuous in the number of target molecules they can bind to, these protein regions increase the number of functions that their small proteome (10 proteins) can achieve. A folding energy waterfall better describes the protein folding landscape of these proteins. A disordered protein can be thought as rolling down the folding energy cascade, in order "to fall, fold and function". This is the case of many viral protein regions, as seen in the flaviviruses proteome. Given their small size, flaviviruses are a good model system for understanding the role of intrinsically disordered protein regions in viral function. Finally, studying these viruses disordered protein regions will certainly contribute to the development of therapeutic approaches against such promising (yet challenging) targets.

中文翻译：

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黄病毒感染中固有的无序蛋白结构域。

本质上无序的蛋白质区域是生物过程的核心，并参与关键的蛋白质-配体相互作用。黄病毒蛋白（具有寨卡病毒和登革热病毒等具有重要生物医学意义的病毒）就是例证。这些病毒的几种蛋白质具有无序区域，这对生物活性至关重要。紊乱的蛋白质可以采用几种构象，每一种都能够与不同的配体相互作用和/或结合。实际上，这种相互作用可以帮助稳定特定的折叠。而且，由于它们可以结合的靶分子数量混杂，这些蛋白质区域增加了其小蛋白质组（10个蛋白质）可以实现的功能数目。折叠能瀑布更好地描述了这些蛋白质的蛋白质折叠态势。可以认为一种无序的蛋白质会降低折叠能量级联，从而“下降，折叠并起作用”。如在黄病毒蛋白质组中所见，这是许多病毒蛋白区域的情况。考虑到它们的体积小，黄病毒是了解内在无序蛋白区域在病毒功能中的作用的良好模型系统。最后，研究这些病毒紊乱的蛋白质区域必将有助于开发针对此类有前途（尚具挑战性）目标的治疗方法。黄病毒是了解内在无序蛋白区域在病毒功能中的作用的良好模型系统。最后，研究这些病毒紊乱的蛋白质区域必将有助于开发针对此类有前途（尚具挑战性）目标的治疗方法。黄病毒是了解内在无序蛋白区域在病毒功能中的作用的良好模型系统。最后，研究这些病毒紊乱的蛋白质区域必将有助于开发针对此类有前途（尚具挑战性）目标的治疗方法。