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Antiemetic prophylaxis in patients undergoing hematopoietic stem cell transplantation: a multicenter survey of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) transplant programs.
Annals of Hematology ( IF 3.5 ) Pub Date : 2020-02-08 , DOI: 10.1007/s00277-020-03945-3
Domenico Pastore 1 , Benedetto Bruno 2 , Paola Carluccio 3 , Maria Stella De Candia 1 , Sonia Mammoliti 4 , Carlo Borghero 5 , Anna Chierichini 6 , Fabio Pavan 7 , Marco Casini 8 , Massimo Pini 9 , Luca Nassi 10 , Raffaella Greco 11 , Francesco Paolo Tambaro 12 , Paola Stefanoni 13 , Giuseppe Console 14 , Francesco Marchesi 15 , Luca Facchini 16 , Alberto Mussetti 17 , Michele Cimminiello 18 , Francesco Saglio 19 , Daniele Vincenti 20 , Sadia Falcioni 21 , Patrizia Chiusolo 22 , Jacopo Olivieri 23 , Annalisa Natale 24 , Maura Faraci 25 , Simone Cesaro 26 , Serena Marotta 27 , Anna Proia 28 , Irene Donnini 29 , Daniela Caravelli 30 , Eliana Zuffa 31 , Anna Paola Iori 32 , Elena Soncini 33 , Valentina Bozzoli 34 , Giovanni Pisapia 35 , Renato Scalone 36 , Oreste Villani 37 , Arcangelo Prete 38 , Antonella Ferrari 39 , Mariacristina Menconi 40 , Giorgia Mancini 41 , Federica Gigli 42 , Gianpaolo Gargiulo 43 , Barbara Bruno 4 , Francesca Patriarca 44 , Francesca Bonifazi 45
Affiliation  

A survey within hematopoietic stem cell transplant (HSCT) centers of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) was performed in order to describe current antiemetic prophylaxis in patients undergoing HSCT. The multicenter survey was performed by a questionnaire, covering the main areas on chemotherapy-induced nausea and vomiting (CINV): antiemetic prophylaxis guidelines used, antiemetic prophylaxis in different conditioning regimens, and methods of CINV evaluation. The survey was carried out in November 2016, and it was repeated 6 months after the publication of the Multinational Association of Supportive Care in Cancer (MASCC)/European Society for Medical Oncology (ESMO) specific guidelines on antiemetic prophylaxis in HSCT. The results show a remarkable heterogeneity of prophylaxis among the various centers and a significant difference between the guidelines and the clinical practice. In the main conditioning regimens, the combination of a serotonin3 receptor antagonist (5-HT3-RA) with dexamethasone and neurokin1 receptor antagonist (NK1-RA), as recommended by MASCC/ESMO guidelines, increased from 0 to 15% (before the publication of the guidelines) to 9-30% (after the publication of the guidelines). This study shows a lack of compliance with specific antiemetic guidelines, resulting mainly in under-prophylaxis. Concerted strategies are required to improve the current CINV prophylaxis, to draft shared common guidelines, and to increase the knowledge and the adherence to the current recommendations for CINV prophylaxis in the specific field of HSCT.

中文翻译:

进行造血干细胞移植的患者的止吐预防:Gruppo Italiano Trapianto Midollo Osseo(GITMO)移植计划的多中心调查。

为了描述正在接受HSCT的患者目前的止吐预防,在Gruppo Italiano Trapianto Midollo Osseo(GITMO)的造血干细胞移植(HSCT)中心内进行了一项调查。该多中心调查是通过问卷进行的,涵盖了化疗引起的恶心和呕吐(CINV)的主要领域:使用的止吐预防指南,不同条件下的止吐预防以及CINV评估方法。这项调查于2016年11月进行,并在多国癌症支持治疗协会(MASCC)/欧洲医学肿瘤学会(ESMO)关于HSCT止吐预防的特定指南发布后重复了6个月。结果显示,各个中心之间在预防方面存在显着的异质性,并且指南与临床实践之间存在显着差异。在主要的调理方案中,根据MASCC / ESMO指南的建议,血清素3受体拮抗剂(5-HT3-RA)与地塞米松和Neurokin1受体拮抗剂(NK1-RA)的组合从0%增至15%(出版前)准则的范围)到9-30%(在准则发布后)。这项研究表明缺乏对特定止吐药指南的依从性,主要是预防不足。需要采取协调一致的策略来改善当前的CINV预防,起草共同的指导方针,并增加对HSCT特定领域中CINV预防的当前建议的了解和遵守。
更新日期:2020-02-10
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