Abstract

Nowadays, one of the most important global goals in medicine is to find ways to control cancer. Magnetic fluid hyperthermia is a promising method for cancer treatment due to its localized influence and low damage to healthy tissue. Ferrite nanoparticles are widely used in this cancer modality because of their low Curie temperature, biocompatibility, and production simplicity. In this work, (Mn_(1−x)Zn_x)Fe₂O₄ sol was obtained by hydrothermal synthesis from chlorides of zinc, manganese, and iron (III) at 180 °C for x = 0.1 and x = 0.2. The results of dynamic light scattering analysis have shown that the average hydrodynamic diameter of nanoparticles in the sol is about 70 nm. According to scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HRTEM), the powdered nanoparticles are spherical with a high degree of crystallinity. X-ray powder diffraction analysis (XRD) has confirmed single-phase formation in samples. The magnetic properties measured have indicated that the nanoparticles have reached temperatures close to the range required for deactivation of cancer cells under the influence of a variable magnetic field.

中文翻译：

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磁热应用（Mn（1-x）Zn x）Fe 2 O 4纳米粒子的合成

摘要

如今，医学上最重要的全球目标之一就是寻找控制癌症的方法。磁流体热疗由于其局部影响和对健康组织的低损害而成为一种有前途的癌症治疗方法。铁氧体纳米粒子由于居里温度低，生物相容性高和生产简单而被广泛用于这种癌症治疗方式。在这项工作中，通过水热合成，由锌，锰和铁（III）的氯化物在180°C下以x  = 0.1和x的形式获得（Mn _{（1- x）} Zn _x）Fe ₂ O ₄溶胶。 = 0.2。动态光散射分析的结果表明，溶胶中纳米颗粒的平均流体动力学直径为约70 nm。根据扫描电子显微镜（SEM）和高分辨率透射电子显微镜（HRTEM），粉末状纳米颗粒是球形的，具有高结晶度。X射线粉末衍射分析（XRD）已确认样品中有单相形成。测得的磁性能表明，在可变磁场的影响下，纳米粒子已达到接近使癌细胞失活所需的温度。