Multiple sclerosis (MS) exhibits neurodegeneration driven disability progression. We compared the extent of neurodegeneration among 112 long-standing MS patients, 37 Parkinson's disease (PD) patients, 34 amnestic mild cognitive impairment (aMCI) patients, 37 Alzheimer's disease (AD) patients, and 184 healthy controls. 3T MRI volumes of whole brain (WBV), white matter (WMV), gray matter (GMV), cortical (CV), deep gray matter (DGM), and nuclei-specific volumes of thalamus, caudate, putamen, globus pallidus, and hippocampus were derived with SIENAX and FIRST software. Аge and sex-adjusted analysis of covariance was used. WBV was not significantly different between diseases. MS had significantly lower WMV compared to other disease groups (p < 0.021). Only AD had smaller GMV and CV when compared to MS (both p < 0.001). MS had smaller DGM volume than PD and aMCI (p < 0.001 and p = 0.026, respectively) and lower thalamic volume when compared to all other neurodegenerative diseases (p < 0.008). Long-standing MS exhibits comparable global atrophy with lower WMV and thalamic volume when compared to other classical neurodegenerative diseases.

中文翻译：

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长期多发性硬化神经变性：体积 MRI 与帕金森病、轻度认知障碍和阿尔茨海默病以及老年人健康对照的比较

多发性硬化症 (MS) 表现出神经变性驱动的残疾进展。我们比较了 112 名长期 MS 患者、37 名帕金森病 (PD) 患者、34 名遗忘型轻度认知障碍 (aMCI) 患者、37 名阿尔茨海默病 (AD) 患者和 184 名健康对照者的神经变性程度。全脑 (WBV)、白质 (WMV)、灰质 (GMV)、皮质 (CV)、深部灰质 (DGM) 和丘脑、尾状核、壳核、苍白球和核特定体积的 3T MRI 体积海马是用SIENAX和FIRST软件导出的。使用年龄和性别调整的协方差分析。WBV 在疾病之间没有显着差异。与其他疾病组相比，MS 的 WMV 显着降低（p < 0.021）。与 MS 相比，只有 AD 的 GMV 和 CV 较小（均 p < 0.001）。与所有其他神经退行性疾病相比，MS 的 DGM 体积小于 PD 和 aMCI（分别为 p < 0.001 和 p = 0.026），并且丘脑体积较小（p < 0.008）。与其他经典神经退行性疾病相比，长期存在的 MS 表现出类似的整体萎缩，WMV 和丘脑体积较低。