Somatic cells can be reprogrammed to pluripotency by either ectopic expression of defined factors or exposure to chemical cocktails. During reprogramming, somatic cells undergo dramatic changes in a wide range of cellular processes, such as metabolism, mitochondrial morphology and function, cell signaling pathways or immortalization. Regulation of these processes during cell reprograming lead to the acquisition of a pluripotent state, which enables indefinite propagation by symmetrical self-renewal without losing the ability of reprogrammed cells to differentiate into all cell types of the adult. In this review, recent data from different laboratories showing how these processes are controlled during the phenotypic transformation of a somatic cell into a pluripotent stem cell will be discussed.

中文翻译：

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诱导多能性的线粒体动力学和代谢。

通过异位表达确定的因子或暴露于化学混合物，可以将体细胞重编程为多能性。在重新编程过程中，体细胞在广泛的细胞过程中发生了巨大变化，例如代谢，线粒体形态和功能，细胞信号通路或永生化。在细胞重编程期间对这些过程的调节导致获得多能状态，这使得能够通过对称的自我更新无限期繁殖，而不会失去重编程细胞分化为成年所有细胞类型的能力。在这篇综述中，将讨论来自不同实验室的最新数据，这些数据显示了在将体细胞表型转化为多能干细胞的过程中如何控制这些过程。