The primary manifestation of rheumatoid arthritis (RA) is articular disease; however, extra-articular disease can also occur. In particular, pulmonary disease is a leading cause of morbidity and mortality in individuals with RA. Herein, we will review the types, prevalence, risk factors, and potential pathophysiology of lung disease in individuals with established RA. We will also discuss the emerging understanding of potential role of the lung in the generation of RA-related autoantibodies during a period of disease development termed "pre-RA." Finally, we will discuss a research agenda outlining the next steps to improve our understanding and management of lung inflammation and lung disease throughout the natural history of RA.

中文翻译：

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类风湿关节炎发病机理中的肺部炎症。

类风湿关节炎（RA）的主要表现是关节疾病。但是，也可能发生关节外疾病。特别是，肺部疾病是RA患者发病和死亡的主要原因。在此，我们将回顾已建立RA的个体的肺部疾病的类型，患病率，危险因素和潜在的病理生理学。我们还将讨论在疾病发展期间称为“ pre-RA”的时期中，肺在与RA相关的自身抗体产生中的潜在作用的新认识。最后，我们将讨论一项研究议程，概述在RA的整个自然史中改善我们对肺部炎症和肺部疾病的理解和管理的下一步措施。