The dual hit hypothesis about the pathogenesis of Parkinson disease (PD) suggests that the brainstem is a convergent area for the propagation of pathological α‐synuclein from the periphery to the brain. Although brainstem structures are likely to be affected early in the course of the disease, detailed information regarding specific brainstem regions is lacking. The aim of our study was to investigate the function of the superior colliculus, a sensorimotor brainstem structure, in de novo PD patients compared to controls using brain functional magnetic imaging and visual stimulation paradigms.

中文翻译：

---

新发帕金森患者上丘视觉功能障碍

关于帕金森病 (PD) 发病机制的双重打击假说表明，脑干是病理性 α-突触核蛋白从外周向大脑传播的汇聚区。尽管脑干结构可能在疾病早期受到影响，但缺乏有关特定脑干区域的详细信息。我们研究的目的是研究上丘（一种感觉运动脑干结构）的功能，与使用脑功能磁成像和视觉刺激范例的对照相比，从头 PD 患者。