The present study aimed at synthesising chitosan bound ginger nanocarriers for slow and controlled release of the drug 5-amino salicylic acid (5-ASA) against inflammatory bowel diseases (IBD). The chitosan, extracted from naturally occurring biopolymer chitin, was reacted to ginger extract (Zingiber officinale) to prepare chitosan-bounded ginger derived nanocarriers (C-GDNC) and further loaded with 5-ASA drug. The as-obtained drug loaded chitosan coated ginger derived nanocarriers (D-C-GNDC) were studied for controlled release of 5-ASA. In vitro experimental data implied slow and controlled release of 5-ASA and were kinetically justified by applying different kinetic models. The obtained percent drug loading capacity and entrapment efficiency were more than 50%. Various experimental factors affecting swelling controlled drug release of 5-ASA, such as change in pH of release medium, chemical composition of nanocarriers, percent drug loading, and simulated biofluids as release media, were investigated. The prepared nanomaterials were well characterized and examined for chemical stability and in vitro cytotoxicity to check their biocompatible nature. The overall studies concluded that the controlled release of 5-ASA was favourable at the gastrointestinal pH which is desirably beneficial against inflammation of bowl.

本研究旨在合成壳聚糖结合的姜纳米载体，以缓慢而受控地释放针对炎症性肠病（IBD）的药物5-氨基水杨酸（5-ASA）。从天然生物聚合物几丁质中提取的壳聚糖与生姜提取物（姜）发生反应）制备壳聚糖结合的生姜纳米载体（C-GDNC），并进一步加入5-ASA药物。研究了获得的载有壳聚糖涂层的生姜纳米载体（DC-GNDC）的药物对5-ASA的控制释放。体外实验数据暗示5-ASA的缓慢释放和受控释放，并且通过应用不同的动力学模型在动力学上是合理的。所获得的载药量百分数和包封率均超过50％。研究了影响5-ASA溶胀控制药物释放的各种实验因素，例如释放介质的pH值变化，纳米载体的化学组成，载药量百分比以及作为释放介质的模拟生物流体。对制备的纳米材料进行了很好的表征，并对其化学稳定性和体外细胞毒性进行了检查，以检查其生物相容性。