Inverse relationship between serum Metrnl levels and visceral fat obesity (VFO) in patients with type 2 diabetes.,Diabetes Research and Clinical Practice

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Inverse relationship between serum Metrnl levels and visceral fat obesity (VFO) in patients with type 2 diabetes.
Diabetes Research and Clinical Practice ( IF 6.1 ) Pub Date : 2020-02-07 , DOI: 10.1016/j.diabres.2020.108068
Yunfeng Du ₁ , Xinhua Ye ₁ , Aijiao Lu ₁ , Dan Zhao ₁ , Juan Liu ₁ , Jinluo Cheng ₁ , Tao Yang ₂

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AIM The relationship between serum Metrnl levels and visceral fat obesity (VFO) remains unclear. This study aimed to investigate the association between serum Metrnl levels and VFO in Chinese patients with type 2 diabetes. METHODS A total of 321 Chinese patients with type 2 diabetes (226 men and 95 postmenopausal women aged 61.4 ± 6.5 years, BMI 25.1 ± 3.2 kg/m2) were evaluated. Serum Metrnl levels were measured by enzyme linked-immunosorbent assay. Visceral fat area (VFA) was quantified via Dual Energy X-ray Absorptiometry (DXA). Correlation analyses were carried out for serum Metrnl levels and VFO. RESULTS VFO groups (VFA ≧100 cm2) have lower serum Metrnl levels than non-VFO groups (VFA < 100 cm2) (578.9 ± 225.1 vs. 684.9 ± 263.8, P = 0.001). An increasing trend in serum Metrnl levels was found to accompany the decrease in VFA. Serum Metrnl levels were negatively correlated with VFA, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and albumin (ALB), but positively correlated with age, height, blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA) (all P < 0.05). Binary logistic regression analysis showed that serum Metrnl was inversely associated with VFO even after adjusted age, gender, height, TC, TG, LDL-C, ALB, BUN, Cr, and UA (odds ration [OR], 0.846; confidence interval [CI], 0.745-0.961; P = 0.010). The optimal cut-off value of serum Metrnl levels that predicted VFO was 671.3 ng/ml (95%CI = 0.55-0.70, P = 0.001). CONCLUSIONS Serum Metrnl levels were inversely correlated with VFO and may be a useful indicator of VFO in Chinese patients with type 2 diabetes.

更新日期：2020-02-07

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