Frailty is emerging as a new category complication of diabetes in older people. Clinically, frailty is still not well defined and mostly viewed as a decline in solely the physical domain. However, frailty is a multidimensional syndrome and the newly introduced concept of "triad of impairment" (physical, cognitive and emotional) may be a more representative of the broad nature of frailty. The components of the triad of impairment (TOI) commonly coexist and demonstrate a reciprocal relation. Diabetes in old age appears to increase the risk of the triad of impairment, which may eventually progress to disability. Therefore, older people with diabetes should be regularly assessed for the presence of these three key components. Adequate nutrition and regular resistance exercise training have been shown to have a positive impact on the long-term outcome in this population. However, the role of good glycaemic control and the use of current hypoglycaemic medications in reducing the incidence of this triad are less clear. Future research is needed to develop novel hypoglycaemic medications that not only focus on glycaemic control and cardiovascular safety but also on reducing the risk of the triad of impairment.

中文翻译：

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患有糖尿病的对等关系老年人的三联征及其临床意义。

衰弱正在成为老年人糖尿病的一种新的并发症。临床上，脆弱性仍未得到很好的定义，通常被视为仅在物理领域的下降。然而，脆弱是一种多维综合症，新引入的“损伤三联征”（身体，认知和情感）概念可能更能代表脆弱的广泛性质。损伤三联征（TOI）的组成部分通常共存并表现出相互关系。老年糖尿病似乎增加了三联征受损的风险，这最终可能会导致残疾。因此，应该定期评估老年人的糖尿病这三个关键因素的存在。事实证明，充足的营养和定期的抵抗运动训练对该人群的长期结局具有积极影响。但是，尚不清楚良好的血糖控制作用和当前使用降血糖药物在降低三联症发病率中的作用。需要开发新的降血糖药物的未来研究，这些药物不仅关注血糖控制和心血管安全，而且还致力于降低三联征受损的风险。