Copper‐Catalyzed Cross‐Coupling of Benzylic Bromides with Arylboronic Acids: Synthesis of Diarylalkanes and Preliminary Antifungal Evaluation Against Magnaporthe Grisea,Asian Journal of Organic Chemistry

当前位置： X-MOL 学术 › Asian J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Copper‐Catalyzed Cross‐Coupling of Benzylic Bromides with Arylboronic Acids: Synthesis of Diarylalkanes and Preliminary Antifungal Evaluation Against Magnaporthe Grisea
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-02-20 , DOI: 10.1002/ajoc.202000007
Zhu Zhu ₁ , Jinggong Liu ₂ , Shoucheng Dong ₁ , Bolai Chen ₂ , Zhenghui Wang ₁ , Ri‐yuan Tang _{1,

3} , Zhaodong Li _{1,

3}

Affiliation

Reported herein is the practical synthesis of 1,1‐diarylalkanes motifs via copper‐catalyzed cross‐coupling reaction of benzylic bromides with arylboronic acids under mild conditions. The protocols show broad scope and good functional group tolerance, and are also applicable to complex natural products. Mechanistic study indicates a radical mechanism. Moreover, preliminary antibacterial evaluation against Magnaporthe grisea is also described for the first time.

中文翻译：

铜催化的苄基溴化物与芳基硼酸的交叉偶联：二芳基烷烃的合成和对灰指甲的初步真菌评价

本文报道的是在温和条件下，通过苄基溴化物与芳基硼酸的铜催化交叉偶联反应，实际合成1,1-二芳基烷烃基序。该协议具有广泛的范围和良好的官能团耐受性，也适用于复杂的天然产物。机理研究表明了一种根本机制。此外，还首次描述了对稻瘟病菌的初步抗菌评估。

更新日期：2020-04-21

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11