BACKGROUND In young women with poor ovarian response, luteal-phase ovarian stimulation (LPOS) is a potential method for collecting competent oocytes. The aim of this study was to assess the efficacy of LPOS compared with follicular phase ovarian stimulation (FPOS) in young women with poor ovarian response (POR). METHODS This single-center, prospective, randomized pilot study compared LPOS and FPOS in women with POR fulfilling Bologna criteria who underwent in vitro fertilization at the Instituto Bernabeu. The primary outcome was the number of metaphase II (MII) oocytes obtained by follicular puncture. RESULTS Sixty women were included in the study, with 27 women completing LPOS and 30 undergoing FPOS. There was no statistically significant difference in the number of MII oocytes obtained between the LPOS group and the FPOS group (2.1 ± 2.0 vs. 2.6 ± 2.2, p = 0.31). Length of stimulation was also similar in both groups (8.35 ± 2.8 vs. 8.15 ± 4.1 days, p = 0.69). Similarly, there was no significant difference in the follicle-stimulating hormone total dose, number of cumulus-oocyte complexes, survival rate, fertilization rate, or cancellation rate between groups. A significantly higher Ovarian Sensitivity Index was observed in the LPOS group versus the FPOS group (0.96 vs. 0.57, p = 0.037). CONCLUSION LPOS was comparable with FPOS in terms of efficacy and may improve ovarian responsiveness in young women with POR. TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT02625532; EudraCT identifier: 2015-003856-31.

中文翻译：

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黄体期刺激与卵泡期刺激在较差的卵巢反应者中：一项随机对照试验的结果。

背景技术在卵巢反应较差的年轻女性中，黄体期卵巢刺激（LPOS）是一种收集卵母细胞的潜在方法。这项研究的目的是评估LPOS与卵泡期卵巢刺激（FPOS）在卵巢反应较差（POR）的年轻女性中的疗效。方法这项单中心，前瞻性，随机试验研究比较了满足博洛尼亚标准且在伯纳乌研究所进行体外受精的POR妇女的LPOS和FPOS。主要结果是通过滤泡穿刺获得的中期II（MII）卵母细胞数量。结果该研究包括60名妇女，其中27名妇女完成LPOS，30名妇女接受FPOS。LPOS组和FPOS组之间获得的MII卵母细胞数量没有统计学上的显着差异（2.1±2.0 vs. 2。6±2.2，p = 0.31）。两组的刺激时间也相似（8.35±2.8 vs. 8.15±4.1天，p = 0.69）。同样，两组之间的促卵泡激素总剂量，卵-卵母细胞复合物的数量，存活率，受精率或消除率也无显着差异。与FPOS组相比，LPOS组的卵巢敏感性指数明显更高（0.96 vs. 0.57，p = 0.037）。结论LPOS在功效上可与FPOS相媲美，并可能改善POR年轻女性的卵巢反应性。试验注册ClinicalTrials.gov标识符：NCT02625532；EudraCT标识符：2015-003856-31。两组之间的卵泡刺激素总剂量，卵丘卵母细胞复合物的数量，存活率，受精率或消除率无显着差异。与FPOS组相比，LPOS组的卵巢敏感性指数明显更高（0.96 vs. 0.57，p = 0.037）。结论LPOS在功效上可与FPOS相媲美，并可能改善POR年轻女性的卵巢反应性。试验注册ClinicalTrials.gov标识符：NCT02625532；EudraCT标识符：2015-003856-31。组之间的促卵泡激素总剂量，卵丘卵母细胞复合物的数量，存活率，受精率或消除率无显着差异。与FPOS组相比，LPOS组的卵巢敏感性指数明显更高（0.96 vs. 0.57，p = 0.037）。结论LPOS在功效上可与FPOS相媲美，并可能改善POR年轻女性的卵巢反应性。试验注册ClinicalTrials.gov标识符：NCT02625532；EudraCT标识符：2015-003856-31。结论LPOS在功效上可与FPOS相媲美，并可能改善POR年轻女性的卵巢反应性。试验注册ClinicalTrials.gov标识符：NCT02625532；EudraCT标识符：2015-003856-31。结论LPOS在功效上可与FPOS相媲美，并可能改善POR年轻女性的卵巢反应性。试验注册ClinicalTrials.gov标识符：NCT02625532；EudraCT标识符：2015-003856-31。