INTRODUCTION/ OBJECTIVES Assuming that there is a link between lipid and glucose metabolism and inflammation in patients with psoriatic arthritis (PsA), our aim was to evaluate the relationships among body composition measurements, food intake, and disease activity in patients with PsA. METHODS A total of 97 patients with PsA, according to the CASPAR criteria, were included in this cross-sectional study. Body composition measurements (whole-body DXA, GE-Lunar), food intake (3-day registry) and biochemical and inflammatory serum markers were evaluated. Skin and joint disease activity were assessed by using PASI, BSA, DAS28, and minimal disease activity (MDA). The level of significance was set as p < 0.05. RESULTS A higher prevalence of obesity, according to the fat mass index (FMI) (92.7%), and metabolic syndrome (MetS) (54%) were found, but no significant changes regarding lean or bone mass were found. Joint disease activity was positively correlated with total body fat (r = 0.4; p < 0.001), FMI (r = 0.33; p < 0.001), body mass index (r = 0.20; p < 0.049) and waist circumference (r = 0.27; p = 0.009). In addition, joint disease activity was negatively associated with muscle mass (r = - 0.38; p < 0.001). Skin disease activity was positively correlated with total cholesterol (r = 0.3; p = 0.003) and LDL-cholesterol (r = 0.28; p = 0.006). After multiple adjustments, patients with severe joint disease activity had higher body adiposity than patients in remission or with low disease activity. Skin disease activity was associated with higher trans-fat intake and lower omega-6 consumption. CONCLUSIONS Our data suggest a possible harmful link among fat (body adiposity, saturated fat consumption, LDL-cholesterol serum levels) and joint and skin disease activity in patients with PsA.

中文翻译：

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银屑病关节炎患者较高的身体肥胖，脂肪摄入和胆固醇血清水平与较高的疾病活动性相关：脂肪和皮肤与关节受累之间是否存在联系？

简介/目的假设银屑病关节炎（PsA）患者的脂质和葡萄糖代谢与炎症之间存在联系，我们的目的是评估PsA患者的身体成分测量，食物摄入与疾病活动之间的关系。方法根据CASPAR标准，本研究共纳入97例PsA患者。评估了人体成分测量（全身DXA，GE-Lunar），食物摄入（3天注册表）以及生化和炎性血清标志物。通过使用PASI，BSA，DAS28和最小疾病活动度（MDA）评估皮肤和关节疾病活动度。显着性水平设定为p <0.05。结果：根据脂肪质量指数（FMI）（92.7％）和代谢综合征（MetS）（54％），肥胖发生率更高，但没有发现关于瘦肉或骨量的显着变化。关节疾病活动与体内总脂肪（r = 0.4; p <0.001），FMI（r = 0.33; p <0.001），体重指数（r = 0.20; p <0.049）和腰围（r = 0.27）正相关； p = 0.009）。此外，关节疾病活动与肌肉质量呈负相关（r =-0.38； p <0.001）。皮肤疾病活动与总胆固醇（r = 0.3； p = 0.003）和LDL-胆固醇（r = 0.28； p = 0.006）呈正相关。经过多次调整后，具有严重关节疾病活动性的患者的身体肥胖率高于处于缓解状态或疾病活动性低的患者。皮肤疾病活动与较高的反式脂肪摄入量和较低的omega-6摄入量有关。结论我们的数据表明脂肪之间可能存在有害联系（人体肥胖，