In this article, a new concept for general pathogenesis has been proposed. Advances in molecular genetics have led to the realization that essential concepts in the framework of molecular biology are still missing. Clinical medicine is plagued by similar shortcomings: The questioning of current paradigms could open new vistas and invite challenging approaches. This article presents an unconventional idea. Foreign DNA which is regularly ingested with the essential food supply is not completely degraded. Small quantities of fragmented DNA rather persist transiently in the gastro-intestinal tract of mice and can be traced to various organ systems, except for cells in the germ line. Foreign DNA entering and persisting in mammalian cells can stochastically lead to genome-wide alterations of transcriptional and CpG DNA methylation profiles. In the course of food-ingested DNA invading somatic cells, completely new cell types can be generated which might be involved in the causation of common ailments. Projects emanating from this perception merit critical analysis and rigorous pursuit.

中文翻译：

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缺少基本概念：食物中的外源DNA入侵生物体的细胞，并可能导致随机的表观遗传改变，并可能产生多种致病性后果。

在本文中，已提出了一般发病机制的新概念。分子遗传学的进步导致人们认识到，分子生物学框架中的基本概念仍然缺失。类似的缺点也困扰着临床医学：对当前范式的质疑可能会打开新的视野，并提出具有挑战性的方法。本文提出了一个非常规的想法。定期与基本食物供应一起摄入的外来DNA不会完全降解。少量片段化的DNA会暂时保留在小鼠的胃肠道中，并且可以追溯到各种器官系统，生殖系中的细胞除外。进入并持续存在于哺乳动物细胞中的外源DNA会随机导致转录和CpG DNA甲基化分布图的全基因组变化。在以食物为食的DNA侵袭体细胞的过程中，可能会产生全新的细胞类型，这可能与常见疾病的病因有关。从这种感知中产生的项目值得进行严格的分析和严格的追求。