BACKGROUND Lung cancer is the most common cause of cancer related death worldwide and survival is poor. Patients with lung cancer may develop a critical illness, but it is unclear what features are associated with an Intensive Care Unit (ICU) admission. METHODS This retrospective, observational, population-based study of linked cancer registration, ICU, hospital discharge and mortality data described the factors associated with ICU admission in patients with lung cancer. The cohort comprised all incident cases of adult lung cancer diagnosed between 1st January 2000 and 31st December 2009 in the West of Scotland, UK, who were subsequently admitted to an ICU within 2 years of cancer diagnosis. Multiple logistic regression was used to determine factors associated with admission. RESULTS 26,731 incident cases of lung cancer were diagnosed with 398 (1.5%) patients admitted to an ICU. Patients were most commonly admitted with respiratory conditions and there was a high rate of invasive mechanical ventilation. ICU, in-hospital and six-month survival were 58.5, 42.0 and 31.2%, respectively. Surgical treatment of lung cancer increased the odds of ICU admission (OR 7.23 (5.14-10.2)). Odds of admission to ICU were reduced with older age (75-80 years OR 0.69 (0.49-0.94), > 80 years OR 0.21 (0.12-0.37)), female gender (OR 0.73 (0.59-0.90)) and radiotherapy (OR 0.54 (0.39-0.73)) or chemotherapy treatment (OR 0.52 (0.38-0.70)). CONCLUSION 1.5% of patients diagnosed with lung cancer are admitted to an ICU but both short term and long term survival was poor. Factors associated with ICU admission included age < 75 years, male gender and surgical treatment of cancer.

中文翻译：

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与肺癌患者重症监护室入院相关的因素：一项针对 26, 731 名患者的基于人群的观察性研究。


背景技术肺癌是全世界癌症相关死亡的最常见原因，并且生存率很低。肺癌患者可能会发展为危重疾病，但尚不清楚哪些特征与入住重症监护病房 (ICU) 相关。方法 这项回顾性、观察性、基于人群的研究涉及癌症登记、ICU、出院和死亡率数据，描述了与肺癌患者入住 ICU 相关的因素。该队列包括 2000 年 1 月 1 日至 2009 年 12 月 31 日期间在英国苏格兰西部诊断的所有成人肺癌病例，这些病例随后在癌症诊断后 2 年内被送入 ICU。使用多元逻辑回归来确定与入院相关的因素。结果 26,731 例肺癌病例被诊断，其中 398 例 (1.5%) 患者入住 ICU。患者最常因呼吸系统疾病入院，并且有创机械通气率很高。 ICU、院内和六个月生存率分别为 58.5%、42.0% 和 31.2%。肺癌的手术治疗增加了入住 ICU 的几率 (OR 7.23 (5.14-10.2))。入住 ICU 的几率随着年龄的增长（75-80 岁 OR 0.69 (0.49-0.94)、> 80 岁 OR 0.21 (0.12-0.37)）、女性（OR 0.73 (0.59-0.90)）和放疗（OR 0.54 (0.39-0.73)) 或化疗治疗 (OR 0.52 (0.38-0.70))。结论 1.5% 诊断为肺癌的患者入住 ICU，但短期和长期生存率都很差。与入住 ICU 相关的因素包括年龄 < 75 岁、男性和癌症手术治疗。