PURPOSE A possible disadvantage of endovascular occlusion outside work hours is that complex procedures might expose patients to additional risk when performed in a suboptimal setting. In this prospective cohort study, we evaluated whether treatment during out of office hours is a risk factor for per-procedural complications and clinical outcome. METHODS We included 471 endovascular-treated, consecutive aneurysmal subarachnoid hemorrhage patients (56.6 ± 13.1, 69% female), from two prospective observational databases which were retrospectively analyzed. Primary outcome was the occurrence of per-procedural complications. Secondary outcomes were good clinical outcome (modified ranking scale ≤ 2) and death at 6-month follow-up. We determined odds ratios (OR) with 95% confidence intervals (CI) by ordered polytomous logistic regression analysis and adjusted odds ratios (aOR) for age, World Federation of Neurosurgical Societies grade, and time to treatment. RESULTS Most patients were treated during office hours (363/471; 77.1%). Treatment during out of office hours did not result in an increased risk of per-procedural complications (OR 0.85 (95% CI 0.53-1.37; p = 0.51). Patients treated during out of office hours displayed similar odds of good clinical outcome and death after 6 months (OR 1.14, 95% CI 0.68-1.97 and 1.16 95% CI 0.56-2.29, respectively) compared to patients treated during office hours. CONCLUSION In our study, endovascular coil embolization during out of office hours did not expose patients to an increased risk of procedural complications or affect functional outcome after 6 months.

中文翻译：

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在非工作时间关闭血管内动脉瘤与并发症或结果无关。

目的在工作时间以外进行血管内阻塞的一个可能的缺点是，在次优环境中进行复杂的手术可能会使患者面临更多的风险。在这项前瞻性队列研究中，我们评估了非工作时间的治疗是否是每个手术并发症和临床结局的危险因素。方法我们回顾性分析了两个前瞻性观察数据库中的471例接受血管内治疗的连续性动脉瘤性蛛网膜下腔出血患者（56.6±13.1，女性69％）。主要结局是按手术并发症的发生。次要结局为良好的临床结局（修订后的评分表≤2）和6个月随访时死亡。我们通过有序多因素逻辑回归分析确定了具有95％置信区间（CI）的比值比（OR），并针对年龄，世界神经外科学会联合会的评分和治疗时间调整了比值比（aOR）。结果大多数患者在办公时间内接受了治疗（363/471; 77.1％）。在非工作时间进行治疗不会增加按手术并发症发生的风险（OR 0.85（95％CI 0.53-1.37； p = 0.51）。在非工作时间接受治疗的患者表现出良好的临床预后和死亡的几率相似与在办公时间内接受治疗的患者相比，在6个月后（OR 1.14、95％CI 0.68-1.97和1.16 95％CI 0.56-2.29）进行了比较。