Computer modeling and simulation is a powerful tool for assessing the performance of medical devices such as bioprosthetic heart valves (BHVs) that promises to accelerate device design and regulation. This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse-duplicator platform that is used in academia, industry, and regulatory agencies to assess BHV performance. These computational models are based on a hyperelastic finite element extension of the immersed boundary method for fluid-structure interaction (FSI). We focus on porcine tissue and bovine pericardial BHVs, which are commonly used in surgical valve replacement. We compare our numerical simulations to experimental data from two similar pulse duplicators, including a commercial ViVitro system and a custom platform related to the ViVitro pulse duplicator. Excellent agreement is demonstrated between the computational and experimental results for bulk flow rates, pressures, valve open areas, and the timing of valve opening and closure in conditions commonly used to assess BHV performance. In addition, reasonable agreement is demonstrated for quantitative measures of leaflet kinematics under these same conditions. This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs.

中文翻译：

---

实验脉冲复制器中生物假体心脏瓣膜动力学的流固耦合模型。


计算机建模和仿真是评估生物人工心脏瓣膜 (BHV) 等医疗设备性能的强大工具，有望加速设备设计和监管。本研究描述了在实验性脉冲复制器平台的主动脉测试部分开发 BHV 动态计算机模型的工作，该平台用于学术界、工业界和监管机构以评估 BHV 性能。这些计算模型基于流固耦合 (FSI) 浸入边界法的超弹性有限元扩展。我们专注于猪组织和牛心包 BHV，它们常用于外科瓣膜置换术。我们将数值模拟与两个类似脉冲复制器的实验数据进行比较，包括商用 ViVitro 系统和与 ViVitro 脉冲复制器相关的定制平台。在通常用于评估 BHV 性能的条件下，总体流量、压力、阀门打开面积以及阀门打开和关闭时间的计算结果和实验结果之间表现出极好的一致性。此外，在这些相同条件下，小叶运动学的定量测量也证明了合理的一致性。这项工作代表了用于评估 BHV 的 FSI 建模平台的实验验证迈出了一步。